Cardiovascular Effects of Conscious Sedation? We read with interest the article by Kaufmann et al about the cardiovascular effects of polymethylmethacrylate (PMMA) injection during percutaneous vertebroplasty (PV). The authors compared patients’ vital signs before with those during and after PMMA injection: no significant differences were noted between preinjection mean arterial pressure (MAP) ...

BACKGROUND The involved neurotransmitter pathways in the postoperative shivering (POS) are poorly understood. Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent POS. We investigated the effect of ondansetron, a 5-HT3 antagonist that is used to treat postoperative nausea and vomiting, on shivering. OBJECTIVES This study aimed to compare the efficacy of o...

Address for correspondence ????????????????????????????? Asian Journal of Medical and Clinical Sciences Short Communication

The purpose of the current study was to determine whether infiltration of bupivacaine in the incision site of midline laparotomy reduces postoperative pain and opioid consumption. Fifty-six, 30-60 year-old patients who were undergoing midline laparotomy were enrolled in the present study. The patients were randomly assigned into two groups of control (group C, n = 28) or bupivacaine (group B, n...

Serotonin syndrome is an unexpected fatal adverse event related to serotonergic medication. This case report is the first report describing the possible treatment effect of famotidine on serotonin syndrome. Furthermore, this is the first case report of serotonin syndrome induced by meperidine alone in a patient with no previous history suggesting a susceptibility to serotonin syndrome. A 70-yea...

This study compares the efficacy of two drug regimens used for oral sedation in pediatric dental patients: chloral hydrate (50 mg/kg)/promethazine (1 mg/kg) and meperidine (1 mg/kg)/promethazine (1 mg/kg). Twenty-four pediatric dental patients, ASA Class I, were evaluated in this double-blind, randomized study. The patients ranged in age from 18 to 48 months. Each dental procedure under sedatio...