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The compound 6-mercaptopurine (6-MP) has been shown to possess definite antitumor (13) properties and to inhibit the growth of several microorganisms (14-16). This inhibition has been reversed by several purines (14-16), and it is possible that the antitumor action is also con cerned with purine metabolism. The present exper iments were undertaken in an attempt to elucidate the action of 6-MP b...

Evidence is presented for the specific interaction of 6-mercaptopurine with mercurated cellulose. Following from this, a new method is described for the affinity chromatography of thiol-containing molecules and of RNA containing incorporated 6-thioguanosine on columns of mercurated cellulose. This technique may find application in the study of RNA metabolism and gene expression.