Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including Parkinson disease. This study aims to differentiate HUC-MSCs into dopaminergic neuron-like cells. Methods: Following the isolation and charac...

Background Mesenchyme stem cells (MSCs) are one of the widely used sources in tissue engineering and efficacy of cultural environment. In this survey, rat stem cells are used as coculture. Owing to main obstacle of embryo culture in the lab medium, the survival of embryo in lab is low in comparison with that of normal conditions. The purpose of this research is the survey of fertilization and c...

Mesenchymal stem cells (MSCs) are self-renewal and multipotent cell source widely existed in mesenchymal tissues, which play a significant role in tissue regeneration and injury repair. It has been reported that MSCs are able to differentiate into multilineage tissue cells, including retinal cells, making MSCs an alternative therapeutic source for some irreversible retinal disorders such as age...

Mesenchymal stromal/stem cells (MSCs) possess the ability to self-renew and differentiate into other cell types. Because of their anti-inflammatory immunomodulatory abilities, as well more ready availability compared stem sources, MSCs hold great promise for treatment many diseases, such haematological defects, acute respiratory distress syndrome, autoimmunity, cardiovascular etc. However, immu...

conclusions taken together, the combination of chemical and growth factors in the two-step induction protocol may improve the efficiency of msc differentiation into neural progenitor cells, and may be a new method for the easy and fast application of mscs in regenerative medicine in the future. results the results of real-time pcr showed that the expression of the gfap, mbp, and map-2 genes aft...

In recent years, globally there is an incredible boost in stem cell research has kindled the expectations of both patients and physicians. Mesenchymal cells (MSCs) seem to represent a future powerful tool regenerative medicine, owing their availability, ease manipulation, therapeutic potential, therefore they are particularly important medical research. capable self-renewing, multipotent progen...

objective(s): stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. the plasticity specification of the adult stem cells, such as mscs, has enabled that these cells to be used in the treatment of a broad spectrum of diseases like liver disorders. in this study, the production of urea and albumin (alb), glycogen storage, and expression of some ...

Mesenchymal stem cells (MSCs) have the capabilities for self-renewal and differentiation into cells with the phenotypes of bone, cartilage, neurons and fat cells. These features of MSCs have attracted the attention of investigators for using MSCs for cell-based therapies to treat several human diseases. Because bone marrow-derived cells, which are a main source of MSCs, are not always acceptabl...

Abstract Background Mesenchymal stem cells (MSCs) provide potential treatments for peritoneal fibrosis. However, MSCs cultured in media containing serum bring risks of infection and other problems. In this study, we compared the effect human serum-free medium (SF-MSCs) on fibrosis with that 10% fetal bovine (10%MSCs). Methods Peritoneal was induced by intraperitoneally injecting 0.1% chlorhexid...