Solitary fibrous tumor (SFT) of prostate is an unusual type of mesenchymal neoplasm that can elicit a benign or malignant phenotype. It represents a diagnostic challenge as it can simulate poorly differentiated adenocarcinoma and various mesenchymal neoplasms of prostate. We report a case of prostate SFT in a 54-year-old patient, which was clinically misdiagnosed as nodular hyperplasia of prost...

Leukemia inhibitory factor (LIF) is a multi-function cytokine. Its role in cancer is not well-understood. Recent studies including ours show that LIF is frequently overexpressed in many types of human tumors and promotes the progression and metastasis of tumors. However, the underlying mechanism of LIF's promoting effects on tumor progression and metastasis is poorly defined. Epithelial-mesench...

Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many studies have reported that tumor progression and metastasis increase by MSCs. In contrast, other studies have shown that MSCs suppress growth of tumors. MSCs contribute to tumor growth promotion by several mechanisms: (1) transition to tumor-associated fibroblasts; (2) suppression of immune response; (3) pro...

Substantial experimental evidence has shown that dedifferentiation from an epithelial state to a mesenchymal-like state (EMT) drives tumor cell metastasis. This transition facilitates tumor cells to acquire motility and invasive features. Intriguingly, tumor cells at the metastatic site are primarily epithelial, and it is believed that they differentiate back to an epithelial state by a process...

Background: Mesenchymal tumors are part of a heterogeneous group neoplasms. Objectives: The present study investigated the clinicopathological properties and surgical outcomes patients with gastric mesenchymal who underwent treatment. Methods: This included all cases treatment for in Başakşehir Çam Sakura City Hospital, Turkey, between August 2020 2022. demographic data clinical patients, opera...

Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP-1 family transcription factor FRA1, a potent regulator of migration and invasion in a variety of tumor cell types. However, the nature of FRA1 tra...

In order to metastasize, cancer cells must undergo phenotypic transition from an anchorage-dependent form to a motile form via a process referred to as epithelial to mesenchymal transition. It is currently unclear whether metastatic cells emerge late during tumor progression by successive accumulation of mutations, or whether they derive from distinct cell populations already present during the...

Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface markers that identify mesenchymal progenitors. An alternative technique to isolate stem-like cells is to isolate side population (SP) cells based on efflux of Hoechst 33342 dye. We examined 29 mesenchymal tumors ranging from benign to high-gra...

Leiomyomas are the most common mesenchymal neoplasms. Smooth muscle cells with variable amounts of fibrous stroma make up these benign tumors. The tumor occurs frequently in uterus 20–30% women reproductive age. Uterine leiomyosarcoma (uLMS/LMS) is a rare cancer originating from smooth lining walls uterus. We report case postmenopausal 65 years presented retention urine, diagnosed as LMS on his...

Cutaneous angiomyolipoma is a rare mesenchymal tumor that demographically, clinically, and immunohistochemically distinct from its renal extrarenal counterparts. We present case of cutaneous in the right retroauricular area 35-year-old male patient provide broad systematic review literature largest compilation angiomyolipomas reported to date. According findings presented this review, we conclu...