The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time...

1 Wisniewski KE, French JH, Rosen JF, Koslowski PB, Tenner M, Wisniewski HM. Basal ganglia calcification (BGC) in Down's syndrome. Another manifestation of premature aging. Ann NYAcad Sci 1982;396:179-89. 2 Jakab I. Basal ganglia calcification and psychosis in mongolism. Eur Neurol 1978;17:300-14. 3 Lowenthal A, De Deyn P. Striopallidodentate calcifications. In: Joseph AB, Young RR, eds. Moveme...

Metabolic syndrome includes the following symptoms: obesity, hyperlipidemia, hypertension, insulin resistance, and cardiovascular disease. The purpose of this review is to elucidate role adipokines in regulation L-arginine-NO-synthas-NO signaling pathway pathogenesis metabolic syndrome. main questions raised are: how adipokine secretion changes, level their receptors regulated, which pathways a...

Amer. J. Med. 27,963 (1959). [7] GORDON, R.: Exsudative enteropathy. Lancet 191)9/1, 325. [8] SCHWARTZ, M., and B. TROMSEN: Idiopathic or hypcrcatabolic hypoproteinaemia. Brit. med. J. 191)7 I, 14. [9] BARANDUN, S., R. AEBERsoLD u. R. BIANCRI: "Proteindiarrhoe". Schweiz. med. Wschr. 90, 1458 (1960). [10] HANIOKI,Z., J.HAWIGER, P.HIRSZEL, and Z. TWARDOWSKI: On some aspects of the antibody defici...