The comprehensive experimental analysis of a metabolic constitution plays a central role in approaches of organismal systems biology. Quantifying the impact of a changing environment on the homeostasis of cellular metabolism has been the focus of numerous studies applying various metabolomics techniques. It has been proven that approaches which integrate different analytical techniques, e.g., L...

The value of metabolomics in translational research is undeniable, and metabolomics data are increasingly generated in large cohorts. The functional interpretation of disease-associated metabolites though is difficult, and the biological mechanisms that underlie cell type or disease-specific metabolomics profiles are oftentimes unknown. To help fully exploit metabolomics data and to aid in its ...

DECONSTRUCTING METABOLOMICS WITHIN NATURAL PRODUCTS: AN INVITATION FOR A DISCUSSION. The metabolomics approach is widespread and accepted in several lines within life sciences. However, much of what has been called could be better defined as a comparison study, regardless its purpose. Metabolomics finds definition the understanding biological properties effects on given organism. In any case, t...

Agilent Technologies is an established leader in providing metabolomics solutions. Metabolomics refers to the identification and quantitation of metabolites, which are the small organic molecules that are used in biological processes within cells. These molecules are important indicators of biological function, and their study can provide unique insights into cell physiology, metabolism, and to...

In this article published in the June 2015 issue of Neoplasia, one of the funding sources was inadvertently omitted. The authors acknowledge CPRIT Core Facility Support Award RP120092 Proteomics and Metabolomics Core Facility for the metabolomics studies. We regret any inconvenience that this has caused.

Metabolomics is the latest of the "omic" technologies that involves comprehensive analysis of small molecule metabolites of an organism or a specific biological sample. Metabolomics provides an insight into the cell status and describes an actual health condition of organisms. Analysis of metabolome offers a unique opportunity to study the influence of genetic variation, disease, applied treatm...

BACKGROUND Metabolomics is increasingly recognized as an invaluable tool in the biological, medical and environmental sciences yet lags behind the methodological maturity of other omics fields. To achieve its full potential, including the integration of multiple omics modalities, the accessibility, standardization and reproducibility of computational metabolomics tools must be improved signific...