Mithramycin A (MTM) and histone deacetylase inhibitors (HDACi) are effective therapeutic agents for cancer and neurodegenerative diseases. MTM is a FDA approved aureolic acid-type antibiotic that binds to GC-rich DNA sequences and interferes with Sp1 transcription factor binding to its target sites (GC box). HDACi, on the other hand, modulate the activity of class I and II histone deacetylases....

Tunable reflecting terahertz bandstop filter based on chirped metamaterial structure is demonstrated by numerical simulation. In the metamaterial, the metal bars are concatenated to silicon bars with different lengths. By varying the conductivity of the silicon bars, the reflectivity, central frequency and bandwidth of the metamaterial could be tuned. Light illumination could be introduced to c...

We studied focusing in a two-dimensional metamaterial that was based on a labyrinth structure. We theoretically showed that the labyrinth-based metamaterial exhibits negative indices of refraction between 6 and 6.4 GHz. We experimentally studied the focusing effect by measuring electric field intensities on the output side of the metamaterial when the source was placed in front of the input sid...

[This corrects the article DOI: 10.1038/mtm.2014.18.].

A highly reliable and efficient communication system is needed for a vehicle to navigate drive the destination without human control (known as an autonomous or self-driving vehicle). In this work, we consider various parameters antenna design, ensuring amongst vehicles infrastructure. Specifically, type of antenna, method used, operating frequency, substrate (with thickness permittivity), size ...

OBJECTIVE To describe events leading to development of a professionwide consensus definition of medication therapy management (MTM) and attendant programs and services and present the document (definition, services, and program requirements) resulting from the process. DATA SOURCES Author's own knowledge and records of events. SUMMARY Following the late 2003 passage of the Medicare Prescrip...

We propose a generalization of the Multipletry Metropolis (MTM) algorithm of Liu et al. (2000), which is based on drawing several proposals at each step and randomly choosing one of them on the basis of weights that may be arbitrary chosen. In particular, for Bayesian estimation we also introduce a method based on weights depending on a quadratic approximation of the posterior distribution. The...

This paper describes the design and simulation of the new Ɛ negative metamaterial unit cell structure and then the unit cells are combined to form 3D array which use as metamaterial cover with a single microstrip patch antenna. The new Ɛ negative metamaterial is based on the ELC resonator structure, which is used for obtaining the negative value of permittivity and positive value of permeabilit...

A metamaterial integration for fiber optics, leading to a dual effect of surface plasmon and classical waveguiding, is presented along with experimental potentiality. We theoretically propose a metamaterial fiber in which, depending on the wavelength (from ultraviolet to infrared) and the particular metamaterial composition, one can transmit information through surface plasmon mediated or class...

To obtain the eigenmodes of the electromagnetic field at a periodically corrugated metamaterial we consider a theory of spoof plasmons propagating on metamaterial perforated with planar periodic grooves. We present the rigorous modeling and analysis of surface waves at the boundary of the corrugated metamaterial structure. Particularly, we pay special attention to the ways of controlling the pr...