Metastatic tumours of the stomach are uncommon finding, usually discovered at autopsy (1). In the same way, gastric metastasis from renal cell carcinoma is uncommon. Brain, spinal cord, and lung are prevalent sites of metastasis from primary renal cell carcinoma (2). The occurrence of gastric metastasis might serve as an indicator of advanced disease and commonly shows concomitant tumour spread...

Renal cell carcinoma is characterized by varied manifestations, which include unusual metastatic sites and paraneoplastic and vascular syndromes. We describe the case of a 57-year-old man who presented with high fever, weight loss, palpitations and a tender goitre. We suggest that, in this patient, subacute thyroiditis manifested as a paraneoplastic syndrome of renal cell carcinoma.

Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case of a 35-year-old male patient who presented with a mass in the left ...

Cardiac masses are rare entities categorized as either neoplastic or non-neoplastic. We present a case of cardiac mass from the inferior vena cava (IVC) extending to right atrium, ventricle and pulmonary artery that was diagnosed by computed tomography (CT), transthoracic echocardiography (TTE), cardiovascular magnetic resonance (CMR) imaging. Differential diagnosis atrial includes myxoma, thro...

A 60-year-old man with renal cell carcinoma developed lung metastases after treatment with left radical nephrectomy (pT3bN0M0, clear cell renal carcinoma, Fuhrman G3 >2). The patient received treatment with gemcitabine and interferon-α and achieved complete response after seven cycles of therapy. However, eight months later, local recurrence was discovered in the renal fossa. We changed the the...

BACKGROUND Long-term survival with durable response remains possible in the area of targeted therapies. Discontinuation of sunitinib could improve quality of life and reduce treatment costs in metastatic renal cell carcinoma with long-term disease stabilization. We discuss a case of successful interruption of antiangiogenic therapy in a patient with persisting evidence of metastases. The discon...

CONTEXT Renal cell carcinoma has shown less response to systemic therapies including chemotherapy, radiotherapy and immunotherapy than other cancers. Metastasis of renal cell carcinoma to the pancreas occurs, even after long term radical nephrectomy, surgical resection remains the only potentially curative intervention. We performed surgery for pancreatic metastatic renal cell carcinoma and ana...

BACKGROUND Chemokine (C-C motif) ligand 21 (CCL21), a ligand of the chemokine (C-C motif) receptor 7, has recently been identified as an immuno-based anti-cancer molecule for its dendritic cells and T lymphocytes chemoattractant function. The aim of this study was to investigate prognostic values of CCL21 expression in metastatic renal cell carcinoma patients treated with targeted therapy. ME...

most types of cancers, and particularly in metastatic renal cell carcinoma, with several drugs currently approved for daily clinical practice. However, secondary resistance to this family of drugs is constantly observed, and the mechanisms of resistance remain poorly understood in patients. Recently, we demonstrated that sunitinib, a tyrosine kinase inhibitor, was able to generate resistance to...

BACKGROUND Renal cell carcinoma is associated with a wide spectrum of para-neoplastic syndromes, which may be precursors of primary or recurrent disease. Non-metastatic hepatic dysfunction in patients suffering from renal cell carcinoma is known as Stauffer's syndrome. It is associated with the production of cytokines by the tumour, and several biochemical abnormalities, including elevated seru...