Prostate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding interactions with E-selectin. We hypothesized that E-selectin ligands on prostate tumor cells are directly associated with bone-metastatic potential. In this report, we elucidate the identity of E-selectin ligands on human met...

Gastrointestinal stromal tumors (GIST) are defined as mesenchymal of the gastrointestinal tract expressing proto-oncogene protein CD 117. GIST is a rare tumor small bowel, which can be difficult to diagnose and has varied clinical outcome. Prognosis dependent on size mitotic count. Radical surgical excision (R0) treatment choice for resectable non-metastatic disease. Imatinib first-line therapy...

To provide a better understanding of the relationship between primary tumor growth rates and metastatic burden, we present a method that bridges tumor growth dynamics at the population level, extracted from the SEER database, to those at the tissue level. Specifically, with this method, we are able to relate estimates of tumor growth rates and metastatic burden derived from a population-level m...

Choriocarcinoma (CC) is a malignant tumor of trophoblastic tissue composed cytotrophoblastic, intermediate and syncytiotrophoblast cells. predominantly has gestational origin. The non-gestational type said to arise from the gonads pluripotent germ It rapidly invasive metastasizes widely, but it good response chemotherapy once identified. Metastatic choriocarcinoma are extremely rare in breast. ...

Head and neck squamous cell carcinoma (HNSCC) is typically diagnosed at advanced stages with evident loco-regional and/or distal metastases. The prevalence of metastatic lesions directly correlates with poor patient outcome, resulting in high patient mortality rates following metastatic development. The progression to metastatic disease requires changes not only in the carcinoma cells, but also...

Osteosarcomas remain one of the most commonly occurring bone cancers in adolescents, accounting for approximately 3% of all diagnosed childhood malignancies. Approximately 30% of osteosarcoma patients develop pulmonary metastatic disease, which is associated with poor prognosis, as 5-year survival rates for these patients are less than 20%. Cytotoxic T-lymphocytes (CTL) likely play an important...

Synovial sarcoma (SS) is a high-grade, rare variant of soft tissue sarcoma (STS). The biphasic subtype is less common than the monophasic subtype. SS is very common around joint cavities in the extremities, but can be present elsewhere in the body. Tumor staging and therapeutic management are usually clear for a localized disease, but the proper management at the metastatic stage can be unclear...

Tumor metastasis accounts for the majority of deaths in cancer patients. The metastatic behavior of cancer cells is promoted by mutations in many genes, including activation of oncogenes such as RAS and MYC. Here, we develop a mathematical framework to analyse the dynamics of mutations enabling cells to metastasize. We consider situations in which one mutation is necessary to confer metastatic ...

To provide a better understanding of the relationship between primary tumor growth rates and metastatic burden, we present a method that bridges tumor growth dynamics at the population level, extracted from the SEER database, to those at the tissue level. Specifically, with this method, we are able to relate estimates of tumor growth rates and metastatic burden derived from a population-level m...