The article is an animal study which addresses an important clinical issue i.e. hypogonadism and low testos-terone levels as a side effect of methadone and buprenor-phine (1). This is not an uncommon side effect which we see in patients receiving long term opioid maintenance treatment. Since methadone has been in use since the 1960s, clinicians became aware of this problem and it is usually add...

the purpose of this research was to determine the efficacy of group schema therapy approach for b category personality disorders score adjustment in substance dependent individuals. the present study was performed on individuals under maintenance treatment with methadone in shiraz public centers. sample group included 30 persons who were under treatment. instruments used included: clinical inte...

BACKGROUND Opioid dependence (OD) is a chronic, relapsing condition representing a significant societal burden in Asia. Opioid maintenance treatment (OMT) in combination with psychosocial treatment is considered to be the most effective strategy to treat opioid dependence. In Malaysia, about 52,000 patients reported receiving OMT in December 2012. OBJECTIVE The International Survey Informing ...

This article describes the history of the heated legal controversy in Germany about prescribing medicinal narcotics. The professional corporations of medical doctors have claimed a right to govem the interpretation and definition of legal terms and for a long time resisted the clinical insights and practical experience about maintenance treatment that had been gathered from abroad. The next log...

This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from...

background methadone effectively alleviates psychiatric disorders. objectives the aim of this study was to evaluate the effectiveness of methadone maintenance therapy in reduction of anxiety and depression among drug-abuser prisoners in ahvaz karoon’s prison. patients and methods in our interventional case-control study, 100 drug-abuser prisoners in ahvaz karoon’s prison, iran, with the symptom...

the current preliminary study aimed to explore the reasons that a group of opiate-dependent patients reported for entry into opium tincture treatment (ott).through examinations of 52 qualitative focus group interviews with patients from six ott centers and 10 health providers (in key informant interviews) in tehran, this study highlights the factors that participants reported as the reasons ass...

OBJECTIVES This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution. METHODS A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was ...

Introduction: Methadone has been an essential medication in the treatment of opioid addiction worldwide. Aim: To discuss dosing considerations related to different methadone programs. Method: A search was performed the Ovid (all resources) including: Medline, Cochrane, and EMBASE databases using the following terms: methadone dose, methadone optimization, and methadone adequacy. We compared and...