MOSES, ARNOLD M. Injuence of adrenal cortex on body water distribution in rats. Am. J. Physiol. 208(4) : 662-665. I 965.Body water distribution was determined in rats by the dilution of serum albumin-1131 and Brs2 and by desiccation. Methylprednisolone (MP) increased the plasma and intracellular compartments and decreased the interstitial volume in intact hydrated rats. The body water moved in ...

BACKGROUND/AIMS Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. MATERIALS AND METHODS Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide d...

We describe the case of a 65-year-old patient with glossopharyngeal neuralgia. Pain was triggered by swallowing, yawning, or cold food. We used the anterior tonsillar pillar method for the injection of drugs; a relatively new glossopharyngeal nerve (GPN) block which was described by Benumof (Anesthesiology 1991;75:1094-1096). Performing this GPN block, daily levobupivacaine (Chirocaine® 5 mg/ml...

Patients and methods 62 patients affected by oligoarticular JIA that referred to our Departments in the period between December 2004 and June 2008, were included in the study. 34 cases (54%) had persistent oligoarthritis and the only affected joints were knee (45%) and ankle (9%). The remaining patients presented extended oligoarthritis and the involved joints, in addition to knee and ankle, we...

OBJECTIVES To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF) and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treatment); G-CSF (G-CSF at the time of injury and daily over the next five days); methylprednisol...

The aim of the present study was to verify whether a single oral dose of methylprednisolone could modulate the exercise-induced release of polymorphonuclear neutrophil (PMN) elastase and myeloperoxidase. Four healthy, male subjects were submitted to a 20 min downhill run (-20%) at 60% VO(2) max, 3 h after oral absorption of a placebo or a single dose of 32 mg methylprednisolone. A marked neutro...

this trial was performed to determine if a continuous low-dose infusion of methylprednisolone is as effective as its bolus of high-dose in reducing inflammatory response. the study was single-center, double-blinded randomized clinical trial and performed in a surgical intensive care unit of an academic hospital. in this study, 72 consecutive patients undergoing elective coronary artery bypass g...

conclusions using a single postsurgical dose of methylprednisolone does not significantly alter the clinical outcome after repairing tetralogy of fallot. results the only significant differences were lower incidence of bacteremia and higher incidence of hyperglycemia in the group who were used methylprednisolone. patients and methods one hundred children who underwent total repair of tetralogy ...