Liver repair after acute liver injury is characterized by hepatocyte proliferation, removal of necrotic tissue, and restoration of hepatocellular and hepatic microvascular architecture. Macrophage recruitment is essential for liver tissue repair and recovery from injury; however, the underlying mechanisms are unclear. Signaling through vascular endothelial growth factor receptor 1 (VEGFR1) is s...

Fetal liver Abelson pre-B cell lines obtained from CBA/Tufts.xid and (CBA/Tufts.xid x CBA/Tufts)F1 mice have complete VDJH rearrangements on at least one allele. Such high frequencies of VDJH rearrangements have previously been observed in adult derived but not fetal liver derived Abelson pre-B cell lines. Genetic analyses suggest that CBA/Tufts.xid carries an autosomal dominant gene(s) that de...

The aim of this study is to investigate the antihyperlipidimic effect Terpenes fraction Iraqi Cicer areitinum in high-fat diet (HFD)-fed mice. Animals were divided into four groups (n =8). total duration was 56 days split two intervals. During first 28-days interval, mice administered with HFD, whereas during second interval they co-administered HFD plus (500mg/kg: p.o.) or standard drug Atorva...

background: alcoholic mothers who consume ethanol give birth to infants with high percentage of hepatic diseases. alcohol can cause cellular damage in different tissues, including liver. finding a drug which is effective and efficient in reducing ethanol misuse consequences during pregnancy can assist the decrease of harmful effects of this habit. objective: this research aims to study the effe...

mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (ebdc), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. the mice were autopsied on 31st day. mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. the mice were autopsied ...

objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...

Successful liver allografts were established by combination with allogeneic bone marrow transplantation. When liver tissue of BALB/c (H-2d) or C57BL/6J (H-2b) mice was minced and grafted under the kidney capsules of C3H/HeN (H-2k) mice, it was rejected. However, when C3H/HeN mice were irradiated and reconstituted with T-cell-depleted BALB/c or BALB/c nu/nu bone marrow cells, or with fetal liver...

Nigella sativa (NS) has a protective effect on cellular damage caused by oxidative stress. Selenium an antioxidative effect. Toxocara canis is one of the nematodes causing visceral larva migrans. Men infected with this parasite ingesting embryonic egg. It more common in children between 1-4 years than adults. From ingested egg, larvae released small intestine and they migrate to so many organs ...

BACKGROUND Ischemia-reperfusion (I/R) injury remains a primary complication of transplant surgery, accounting for about 80% of liver transplant failures, and is a major source of morbidity in other pathologic conditions. Activation of endothelium and inflammatory cell recruitment are central to the initiation and promulgation of I/R injury, which can be limited by the bioactive gas nitric oxide...

Presenter: Joshua Leinwand MD | Columbia University Background: The gut microbiome shapes local and systemic immunity. liver, much like the gut, is densely populated by myriad innate adaptive immune cells that are critical in physiologic homeostasis, serves as a selective barrier between host environment via portal circulation. While translocation of bacteria from other sites to liver has been ...