Mammals are serially infected with a variety of microorganisms, including bacteria and parasites. Each infection reprograms the immune system's responses to re-exposure and potentially alters responses to first-time infection by different microorganisms. To examine whether infection with a metazoan parasite modulates host responses to subsequent bacterial infection, mice were infected with the ...

We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.

Radioimmunotherapy (RIT) and radiotherapy (RT) were evaluated in nude mice developing liver metastases of human colon cancer. Without treatment, 90% of preconditioned nude mice, injected with LS174T cells intrasplenically and splenectomized, died between 26 and 93 days after grafting with few to several hundred liver metastases. RIT with 500 microCi of 131I-labeled anti-carcinoembryonic antigen...

(wheren is numberof mice),wasusedto test levels of significance. One hundred and thirty-one female mice belonging to litters 4—11within the same latent period class (latent period < 100 days) lived, on an average, [email protected] days. This is a median value of 99.0 ± @.4days. There is a difference of 33.0 ±3.4 days between the two groups. This is 9.6 X P.E. Thus, there is a significant increase of su...

Abstract Efficient immune responses rely on heterogeneity, which in CD8 + T cells, amongst other mechanisms, is achieved by asymmetric cell division (ACD). Here we find that ageing, known to negatively impact responses, impairs ACD murine and this phenotype can be rescued transient mTOR inhibition. Increased rates mitotic cells from aged mice restore the expansion memory potential of their cell...

background: the adjuvanticity potential of lactobacillus casei was first suggested in an old survey. the present study was designed to investigate the efficacy of a new immunotherapy against breast cancer made by mixing an extract of heated 4t1 mammary carcinoma cell line and a heat-killed preparation of lactobacillus casei. methods: female balb/c mice (6–8 weeks old, n=40) were challenged subc...

Taoxoplasma gondii is an important food-borne parasite transmitted primarily from animals to humans through meat consumption, mainly pork and lamb, as well as through oocysts shed by cats. Infection in humans can cause severe fetal malformations, ocular complications or encephalitis. Toxoplasmosis infection during pregnancy, especially in sheep, often results in abortion, representing considera...