a simple extractive spectrophotometric method has been developed for the estimation of miconazole nitratein both pure and pharmaceutical preparation. the method is based on the formation of ion-pair complex of thedrug with acidic dye bromothymol blue (btb) in acidic condition, followed by its extraction in organic solvent(chloroform). the absorbance was measured against the corresponding blank....

Treatment of rat intestinal epithelial cells (IEC-6 cells) with lanosterol 14 alpha-demethylase inhibitors, ketoconazole and miconazole, had similar effects on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and cholesterol biosynthesis but the drugs differed in their ability to prevent the low density lipoprotein (LDL) suppression of reductase activity. Miconazole, at concen...

Susceptibility to amphotericin B, miconazole, and ketoconazole was determined for 25 clinical isolates of zygomycetes in yeast nitrogen base broth and human serum. In yeast nitrogen base broth, 7 of 25 isolates were susceptible to an imidazole or amphotericin B. In serum, all were resistant to the imidazoles and inhibited by amphotericin B, the current drug of choice for infections caused by zy...

A diffusion method for determining the sensitivity of pathogenic fungi to therapeutic agents is described using tablets containing the following antibiotics: amphotericin B, clotrimazole, econazole, fluorocytosine, and miconazole. The composition of the media used, standardisation of inocula, incubation time, and temperature are detailed.