Micromechanics design theory has realized Random Short Fiber Reinforced Cement Composites (RSFRCC) showing Pseudo Strain Hardening (PSH) behavior with over 5 % of strain capacity under tension. Nevertheless, this existing theory is currently limited to specific constituent properties, which does not account for chemical bond and fiber rupture. This article presents a new design theory which eli...

The wormlike chain model describes the micromechanics of semiflexible polymers by introducing the persistence length. We propose a method of measuring the persistence length of DNA in a controllable near-native environment. Using a dark field microscope, the projected positions of a gold nanoparticle undergoing constrained Brownian motion are captured. The nanoparticle is tethered to a substrat...

Denosumab, a fully human monoclonal antibody, has been approved for the treatment of postmenopausal osteoporosis. The therapeutic effect of denosumab rests on its ability to inhibit osteoclast differentiation. Here, we present a computational approach on the basis of coupling a pharmacokinetics model of denosumab with a pharmacodynamics model for quantifying the effect of denosumab on bone remo...

The micromechanics design theory has realized random short fiber-reinforced cement composites showing pseudostrain hardening (PSH) behavior with over 5% of strain capacity under tension. Nevertheless, this existing theory currently is limited to specific constituent properties, which does not account for chemical bond and fiber rupture. This article presents a new design theory that eliminates ...

Understanding the sediment transport in oscillatory flows is essential to the investigation of the overall sediment budget for coastal regions. This overall budget is crucial for the prediction of the morphological change of the coastline in engineering applications. Since the sediment transport in oscillatory flows is dense particle-laden flow, appropriate modeling of the particle interaction ...