Crystallization is a key unit operation in the pharmaceutical industry. Control of crystallization processes can be challenging when undesirable phenomena such as particle attrition and breakage occur. This thesis describes the controlled crystallization of pharmaceuticals and amino acids for more efficient manufacturing processes and better efficacy of products. Crystallization equipment is de...

Micromixer is a significant component of microfluidics particularly in lab-on-chip applications so that there has been a growing need for design and fabrication of micromixers with a shorter length and higher efficiency. Despite most of the passive micromixers that suffer from long mixing path and complicated geometry to increase the efficiency, our novel design suggests a highly efficient micr...

Focusing on Large Eddy Simulation (LES) in the scalar field, this work has threefoldachievement:The development, validation and application of a new anisotropy subgrid scale (SGS)model that is designed to better describe the behavior of SGS scalar flux transportIn the frame of LES, a new developed anisotropy model is proposed and implemented.Unlike the isotropic SGS scalar f...

Stirred tanks are widely used in process industries for blending of singleand/or multiple-phase fluids, which often involves mass and/or heat transfer, chemical reactions, etc. Deep knowledge of flow field in the stirred tank is necessary to carry out these unit operations efficiently. As a result, extensive investigations of the flow in stirred tanks have been conducted over the past several d...

Novel microfluidic technologies being developed for portable diagnostic systems have potential for use in TB serodiagnosis or as platforms for cell and biomolecular assays. Using microfluidics, with its miniaturized channels and reservoirs for portable devices, offers many advantages, including: high surface-to-volume ratio; a low Reynolds number; increased speed of reaction; reduced cost of re...

Though uncommon in most microfluidic systems due to the dominance of viscous and capillary stresses, it is possible to drive microscale fluid flows with considerable inertia using surface acoustic waves (SAWs), which are nanometer order amplitude electro-elastic waves that can be generated on a piezoelectric substrate. Due to the confinement of the acoustic energy to a thin localized region alo...

Turbulent mixing of fluids plays a dominating role in a large number of engineering devices such as combustion chambers, burners, injection systems and heat exchangers. Especially in the context of chemical applications exploration of physical mechanisms of mixing processes is extremely important to control the chemical reactions. Solution of this problem is based on detailed analysis of both h...

Till recently, the application of the detailed combustion chemistry approach as a predictive tool for engine modeling has been a sort of a ”taboo” motivated by different reasons, but, mainly, by an exaggerated rigor to the chemistry/turbulence interaction modeling. The situation has drastically changed only recently, when STAR-CD and Reaction Design declared in the Newsletter of Compuatational ...

A spray sonocrystallization (SSC) method is described here for the crystallization of pharmaceutical agents that provides for a tunable crystal size and narrow size distribution in the submicron regime. SSC uses a tapped, flow-through ultrasonic horn (20 kHz) to spray very fine droplets of the solute-containing solution into a continuous flow of antisolvent which induces immediate crystallizati...

A continuous microflow system was developed with efficient catalyst recycling for a Mizoroki-Heck reaction of iodobenzene with butyl acrylate, using a low-viscosity ionic liquid ([bmim]NTf2) as the reaction medium. Using a CPC CYTOS Lab System as the microreaction apparatus, in combination with an originally developed microextraction/catalyst recycling system, the reaction medium, which contain...