A novel reversible fluorescent switch of a polydiacetylene liposome (PDA liposome) was realized by alternating heating and UV irradiation processes. The reversible fluorescence switching of the PDA liposome was mainly caused by the microstructural changes of the PDA backbone in the PDA liposomes under the alternating conditions of heating and UV irradiation.

In combining biomechanical investigations with microanatomical studies, the authors have found new evidence suggesting a mechanobiological link between the altered microstructural response of degenerate cartilage to load, and the way in which structural changes develop in the early osteoarthritic joint. This paper presents the data and background for a new hypothesis exploring the initiation an...