objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

OBJECTIVES To report the prevalence and characteristics of headaches in veterans with mild traumatic brain injury (TBI) and to describe most common treatment strategies after neurological evaluation. METHODS We conducted a retrospective cohort study. The setting was a United States Veterans Healthcare Administration Polytrauma Network Site. The study participants consisted of 246 veterans wit...

Polydipsia and polyuria associated with traumatic spinal cord injury (SCI) are rare consequences. The hypothetical pathophysiological mechanisms involve mild brain (TBI) and/or vagus dysfunction injury. In a retrospective study of 11 patients, we investigated associations between polydipsia-polyuria syndrome various clinical therapeutic factors: medullary section syndrome, neurological level, m...

Objective(s): Cognitive defects such as learning and memory impairment are amongst the most repetitious sequelae after sever and moderate traumatic brain injury (TBI). It was suggested that ellagic acid (EA), an innate phenol product, display neuroprotective properties against oxidative and inflammatory damages after brain injury. The object of the current study was therapeutic properties of EA...

There is increasing evidence that some people can experience persistent symptoms for up to a year following mild TBI. However, few longitudinal studies of mild TBI exist and the longer-term impact remains unclear. The purpose of this study is to determine if there are long-term effects of mild traumatic brain injury (TBI) four-years later. Adults (aged ≥16 years) identified as part of a TBI inc...

Abstract Date Presented 04/21/2023 This study investigates the impact of self-regulation on reengagement in leisure activities with adults traumatic brain injury (TBI). Reengagement significantly decreases after TBI, apathy being a significant predictor this outcome. Primary Author and Speaker: Amanda Gahlot Contributing Authors: Denise Krch, Yael Goverover

PRIMARY OBJECTIVE The aim of this study was to examine the complex inter-relationship between subjective reports of cognitive impairments and neuropsychological performances in compensation-seeking individuals with traumatic brain injury (TBI) of differing severities. Specifically, this study examined: (a) the participants' neuropsychological test scores and self-reported ratings according to T...

The risk of developing an addiction to alcohol, tobacco, or drugs increases in the period immediately following mild traumatic brain injury (mTBI) but decreases over time, new research shows. historical prospective study showed that short-term, individuals with mTBI had a significantly increased for alcohol dependence, nicotine and nondependent abuse compared similarly injured non-mTBI comparis...

Abstract Objective To compare neurocognitive outcomes between 3 traumatic brain injury (TBI) groups (mild, moderate, severe) across TBI classification systems: Glasgow Coma Scale (GCS) and Russell (mild <1 hour, moderate <24 hours severe >24 hours) the modified hours, < one week > week) posttraumatic amnesia (PTA) systems. Method Private practice archival data...

Emotional disorders are a common outcome from mild traumatic brain injury (TBI) in humans, but their pathophysiological basis is poorly understood. We have developed a mouse model of closed-head blast injury using an air pressure wave delivered to a small area on one side of the cranium, to create mild TBI. We found that 20-psi blasts in 3-month-old C57BL/6 male mice yielded no obvious behavior...