A family of cationic lipids was synthesized via direct amide coupling of spermine to the C-24 position of cholic acid analogs. Four monosubstituted spermines and a bis-substituted spermine were evaluated as plasmid transfection reagents, as bacteriostatic agents, and as bactericidal agents. The incorporation of a double bond in the sterol moiety enhanced transfection efficiency significantly an...

gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. gentamicin is active against the majority of aerobic gram-negative bacilli such as pseudomonas, klebsiella and escherichia coli. the gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. the monitoring of gentamici...

Nowadays, uncontrolled and frequent use of antibiotics may cause emergence of microbial resistanceamong pathogenic agents. Therefore, the use of new synthetic and natural antimicrobial compounds isinevitable. One source of natural compounds in this respect comes from plants. The purpose of this study was to examine the antibacterial effects of peel extracts from sour and sweet pomegranate. Meth...

The objective of this study is to report the comparative chemical analysis of essential oil (EO) obtained by hydrodistillation (HD) and volatile fraction (VF) detected by headspace solid phase micro-extraction (HS–SPME) isolated from Pulicaria mauritanica using Gas Chromatography–Retention Indices (GC-RI) and GC–Mass Spectrometry (GC-MS) and to evaluate in vitro the antimicrobial activity of P....

Increasing bacterial resistance to commercial antibiotics has led to considering medicinal herb applications. This study aimed to identify chemical composition of essential oil of some native medical herbs and their antibacterial activity against Yersinia ruckeri compared with Enrofloxacin in in vitro experiments. The antibacterial activities of ethanolic extracts and essential oils of Eryngium...

INTRODUCTION Ceftolozane/tazobactam is an antibacterial agent with potent in vitro activity against Gram-negative pathogens, including many extended-spectrum β-lactamase-producing Enterobacteriaceae and drug-resistant Pseudomonas aeruginosa. Because ceftolozane/tazobactam is primarily excreted renally, appropriate dose adjustments are needed for patients with renal impairment. Monte Carlo simul...

Background and objectives: Evaluating the safety of pharmaceutical products by in vitro methods like cell culture, and in vivo tests on animals, is one of the regulatory steps in development of drugs which is called the preclinical stage. If acceptable results are obtained, the drug can be used in clinical studies. In this study, we have investigated the cytot...

Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediterranean natural extracts on oral microorganisms. Five different extracts from O...

Listeria monocytogenes is an important foodborne pathogen implicated in many outbreaks of listeriosis. This study aimed at screening for the potential use of Rhodomyrtus tomentosa ethanolic leaf extract as a bio-control agent against L. monocytogenes. Twenty-two L. monocytogenes isolates were checked with 16 commercial antibiotics and isolates displayed resistance to 10 antibiotics. All the tes...