PURPOSE To identify whether static and dynamic aspects of accommodation other than accuracy are deficient in individuals with Down syndrome (DS) and whether poor accommodation is related to sensory or motor pathway deficits. METHODS Static aspects of accommodation (maximum accommodative response and lag) were measured with an autorefractor for both proximal and minus lens demands. Dynamic asp...

The relationship between the increase in catecholamine levels of the coronary sinus blood and the amplitude of various cardiac responses to adrenergic nerve stimulation was studied in anesthetized dogs. Plasma catecholamine levels in both coronary sinus and aortic blood were measured by a modification of the radiometric enzymatic assay for tissue catecholamines and were found to be 0.622 plus o...

OBJECTIVE To examine test characteristics of laser Doppler vasomotor reflex testing for leprosy and to determine the prevalence of abnormal responses in leprosy patients, healthy contacts and controls. DESIGN AND PARTICIPANTS Cross-sectional study including 89 leprosy patients (mean age 35 years, 74% male), 36 healthy contacts (29 years, 64% male) and 47 controls (30 years, 68% male), for a t...

Knowles, Das Gupta and Sen (1936) have observed that 15 of a batch of 31 white mice (Mus muscuius) showed spontaneous infection with Spirillum minus. These mice were caged in cages of narrow meshed iron-netting. No rat could possibly get at the mice to bite them. On looking through the literature it is found that other workers such as Robertson (1930), McCluskie (1930), and lately Francis (1936...

George A. Miller said that human beings have only seven chunks in short-term memory, plus or minus two. We counted the number of bunsetsus (phrases) whose modifiees are undetermined in each step of an analysis of the dependency structure of Japanese sentences, and which therefore must be stored in short-term memory. The number was roughly less than nine, the upper bound of seven plus or minus t...

UNLABELLED In a previous study we have shown that the antihypertensive drug, urapidil, stops postanesthetic shivering. One possible mechanism in the inhibition of postanesthetic shivering by urapidil may be alterations in thermoregulatory thresholds. We therefore studied the effects of urapidil on vasoconstriction and shivering thresholds during cold-induced shivering in volunteers. Seven healt...

Microtubules are intrinsically polar structures. A consequence of this polarity is that the two ends of the microtubule polymer exhibit different properties. The more dynamic plus ends and the mechanisms that regulate their behavior have been the focus of much recent attention. Here, we concentrate on the dynamics and regulation of minus ends, which play distinct but equally critical roles in m...

OBJECTIVES The purpose of this study was to evaluate an implantable cardioverter-defibrillator (ICD) incorporating biventricular pacing. BACKGROUND Biventricular pacing improves the symptoms of heart failure, a frequent problem in ICD recipients. METHODS This prospective multicenter study evaluated the safety and efficacy of an ICD with biventricular pacing. RESULTS A total of 84 patients...

The possibility that bradykinin, a potent vasodilator, might be a physiological antagonist of the renin-angiotensin system was investigated. 11 norman subjects, ranging in age from 21 to 33 yr were studied. Seven of the subjects were given a 10 meq sodium, 100 meq potassium, 2500 ml isocaloric diet. After metabolic balance was achieved, they were infused with either 1 liter of 5 per cent glucos...