نتایج جستجو برای: mirna اینترونی مصنوعی

تعداد نتایج: 33577  

Journal: :Data 2023

MicroRNA transcriptomes from fresh tumors and the adjacent normal tissues were profiled in 10 Korean patients diagnosed with lung adenocarcinoma using a next-generation sequencing (NGS) technique called miRNA-seq. The quality was assessed FastQC, low-quality or adapter-contaminated portions of reads removed Trim Galore. Quality-assured analyzed miRDeep2 Bowtie. abundance known miRNAs estimated ...

2010
Ingo Büssing Jr-Shiuan Yang Eric C Lai Helge Großhans

MicroRNA (miRNA) biogenesis proceeds from a primary transcript (pri-miRNA) through the pre-miRNA into the mature miRNA. Here, we identify a role of the Caenorhabditis elegans nuclear export receptor XPO-1 and the cap-binding proteins CBP-20/NCBP-2 and CBP-80/NCBP-1 in this process. The RNA-mediated interference of any of these genes causes retarded heterochronic phenotypes similar to those obse...

2017
Tingming Liang Jiafeng Yu Chang Liu Li Guo

Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3'addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer‑independent miRNA loci by conducting evolutionary and expression analysis using public datasets. ...

Journal: :Cancer Biology & Therapy 2012

Journal: :International journal of statistics in medical research 2022

Background/Purpose: Oral Squamous cell carcinoma is sixth most common cancer with considerable morbidity and mortality. The microRNAs (miRNAs) are set of short RNAs involved in regulating the expression protein coding genes. They up or down-regulated carcinogenesis oral cancer. miRNA-31 (miR-31) increased Objective: To evaluate compare plasma squamous control subjects. Materials Methods: Case s...

Journal: :PLOS Pathogens 2021

The host response to SARS-CoV-2 infection provide insights into both viral pathogenesis and patient management. host-encoded microRNA (miRNA) infection, however, remains poorly defined. Here we profiled circulating miRNAs from ten COVID-19 patients sampled longitudinally age gender matched healthy donors. We observed 55 that were altered in during early-stage disease, with the inflammatory miR-...

Journal: :Blood 2008
Andrea J O'Hara Wolfgang Vahrson Dirk P Dittmer

MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)-based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PEL-specifi...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2021

Objective: Our aim was to characterize distinctive clinical antiphospholipid syndrome phenotypes and identify novel microRNA (miRNA)-mRNA-intracellular signaling regulatory networks in monocytes linked cardiovascular disease. Approach Results: Microarray analysis revealed 547 differentially expressed genes, mainly involved inflammatory, cardiovascular, reproductive disorders. Besides, this appr...

Journal: :Journal of Immunology 2021

Abstract Protein arginine methyltransferase-1 (PRMT1) is an important epigenetic regulator of cell function and contributes to inflammation remodeling in asthma a type–specific manner. Disease-specific expression patterns microRNAs (miRNA) are associated with chronic inflammatory lung diseases, including asthma. The de novo synthesis miRNA depends on the transcription primary (pri-miRNA) transc...

2009
Andrea J. O’Hara Dirk P. Dittmer Shawn Ahmed Blossom Damania Morgan Giddings Ronald I. Swanstrom William F. Marzluff Andrea O’Hara

MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)–based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PELspecific...

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