نتایج جستجو برای: mirna اینترونی مصنوعی
تعداد نتایج: 33577 فیلتر نتایج به سال:
MicroRNA transcriptomes from fresh tumors and the adjacent normal tissues were profiled in 10 Korean patients diagnosed with lung adenocarcinoma using a next-generation sequencing (NGS) technique called miRNA-seq. The quality was assessed FastQC, low-quality or adapter-contaminated portions of reads removed Trim Galore. Quality-assured analyzed miRDeep2 Bowtie. abundance known miRNAs estimated ...
MicroRNA (miRNA) biogenesis proceeds from a primary transcript (pri-miRNA) through the pre-miRNA into the mature miRNA. Here, we identify a role of the Caenorhabditis elegans nuclear export receptor XPO-1 and the cap-binding proteins CBP-20/NCBP-2 and CBP-80/NCBP-1 in this process. The RNA-mediated interference of any of these genes causes retarded heterochronic phenotypes similar to those obse...
Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3'addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer‑independent miRNA loci by conducting evolutionary and expression analysis using public datasets. ...
Background/Purpose: Oral Squamous cell carcinoma is sixth most common cancer with considerable morbidity and mortality. The microRNAs (miRNAs) are set of short RNAs involved in regulating the expression protein coding genes. They up or down-regulated carcinogenesis oral cancer. miRNA-31 (miR-31) increased Objective: To evaluate compare plasma squamous control subjects. Materials Methods: Case s...
The host response to SARS-CoV-2 infection provide insights into both viral pathogenesis and patient management. host-encoded microRNA (miRNA) infection, however, remains poorly defined. Here we profiled circulating miRNAs from ten COVID-19 patients sampled longitudinally age gender matched healthy donors. We observed 55 that were altered in during early-stage disease, with the inflammatory miR-...
MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)-based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PEL-specifi...
Objective: Our aim was to characterize distinctive clinical antiphospholipid syndrome phenotypes and identify novel microRNA (miRNA)-mRNA-intracellular signaling regulatory networks in monocytes linked cardiovascular disease. Approach Results: Microarray analysis revealed 547 differentially expressed genes, mainly involved inflammatory, cardiovascular, reproductive disorders. Besides, this appr...
Abstract Protein arginine methyltransferase-1 (PRMT1) is an important epigenetic regulator of cell function and contributes to inflammation remodeling in asthma a type–specific manner. Disease-specific expression patterns microRNAs (miRNA) are associated with chronic inflammatory lung diseases, including asthma. The de novo synthesis miRNA depends on the transcription primary (pri-miRNA) transc...
MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)–based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PELspecific...
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