A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter ...

INTRODUCTION This case report describes the effects of psychotropic treatment, quetiapine in particular, on systemic inflammation, pain, general functioning and major depression in the treatment of a woman with arthritis. CASE PRESENTATION A 49-year-old Caucasian Australian woman with arthritis, pain and depression was treated with a course of escitalopram, mirtazapine and quetiapine. Pain le...

A rapid and sensitive HPLC method has been developed for the quantification of mirtazapine (MRZ), a noradrenergic and specific serotonergic inhibitor antidepressant (NaSSA) and its two major metabolites N-desmethyl mirtazapine (NDM) and 8-hydroxymirtazapine (8-OHM) in human plasma. The separation was achieved using Chromolith C18 column and a mobile phase of acetonitrile: phosphate buffer (pH =...

INTRODUCTION A assess the efficacy of mirtazapine in the treatment of depression with somatic symptoms in a 3-months follow-up study. MATERIAL AND METHODS DESIGN multicenter, prospective, observational, open-label, and non controlled study. SAMPLE seven hundred and eleven patients recruited in outpatient psychiatric consultations by 98 psychiatrists nationwide. INSTRUMENTS 17-Item Hami...

Agitation is one of the most devastating behavioral symptoms in demented patients but there is little evidence about effective and safe pharmacotherapy. We aimed to determine the effectiveness and safety of mirtazapine in treatment of agitated patients with Alzheimer's disease (AD). The consecutive patients with AD who have significant agitation were assigned to a 12-week open-label, prospectiv...

OBJECTIVES This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. MATERIALS AND METHODS Diabetic rats were divided into a...

Poor-insight obsessive-compulsive disorder (PI-OCD) is a severe form of OCD where the 'typically obsessive' features of intrusive, 'egodystonic' feelings and thoughts are absent. PI-OCD is difficult to treat, often requiring very high doses of serotonergic drugs as well as antipsychotic augmentation. When this occurs, unpleasant side effects as nausea are common, eventually further reducing com...

The reader needs to be aware of the following information. On June 27, 2006, Cypress Bioscience Inc. announced “that the results of recently completed Phase IIa trials do not support continuing a development program evaluating combinations of mirtazapine with another approved drug as potential pharmaceutical treatments for obstructive sleep apnea (OSA). Cypress and Organon, the human healthcare...

The newer antidepressant venlafaxine is known to cause dilutional hyponatraemia, but to our knowledge no reports on localized oedemas in the absence of electrolyte disturbances are available. We present a case in which venlafaxine caused reversible blepharoedema in an otherwise physically healthy patient. Ms. M., a 25-yr-old women, suffered from schizoaffective disorder since being 23 years old...