BACKGROUND Mixed methods research, the use of both qualitative and quantitative methods within 1 program of study, is becoming increasingly popular to allow investigators to explore patient experiences (qualitative) and also measure outcomes (quantitative). Coronary artery disease and its risk factors are some of the most studied conditions; however, the extent to which mixed methods studies ar...

This study produced simple linear regression equations to be used for mixed dentition space analysis for males and females, and sexes pooled in a population living in northeastern Thailand. Measurements of teeth were made to within 0.01 mm on the dental casts of 215 boys and 215 girls (mean age 15.7 years). All dentitions were required to be free of any signs of dental pathology or anomalies. I...

BackgroundMixed connective tissue disease (MCTD) is a rare and complex autoimmune that presents mixed features with other diseases, such as systemic lupus erythematosus, sclerosis, myositis. It characterized by high levels of anti–U1 small nuclear ribonucleoprotein 70k autoantibodies incidence life-threatening pulmonary involvement. The pathophysiology MCTD not well understood, no specific trea...

A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that it is superior to the standard generalized linear mixed model in this context. Here, we call trivariate vine copulas to extend the bivariate meta-analysis of diagnostic test accuracy studies by accounting for disease prevalence. Our vine copula mixed model includes...