Mitomycin C (MMC) induced aerobic and hypoxic Cytotoxicity in Chinese hamster V79 cells was studied to evaluate the role of the 1electron versus 2-electron reductive bioactivation. Superoxide dismutase, catatase, and desierai had no protective effects on the aerobic or hypoxic Cytotoxicity of MMC, whereas Tempol and Tempol-H, which are known to interrupt and terminate radical reactions, provide...

background: children with myelomeningocele (mmc) develop a wide variety of hip deformities such as muscle imbalance, contracture, subluxation, and dislocation. various methods and indications have been introduced for treatment of muscle imbalances and other hip problems in patients with mmc but there is no study or meta-analysis to compare the results and complications. this review aims to find...

Mitomycin C (MMC) induced aerobic and hypoxic Cytotoxicity in Chinese hamster V79 cells was studied to evaluate the role of the 1electron versus 2-electron reductive bioactivation. Superoxide dismutase, catatase, and desierai had no protective effects on the aerobic or hypoxic Cytotoxicity of MMC, whereas Tempol and Tempol-H, which are known to interrupt and terminate radical reactions, provide...

PURPOSE The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair. METHODS Quiescent keratocytes cultured in serum-free media were exposed to various concentrations of MMC and then treated with transforming growth factor-β (TGFβ). DNA damage ...

of Purpose: A comparison of long term effect on IOP and complications trabeculectomies performed with the adjunct of either postoperative 5 fluorouracil(5FU) or peroperative mitomycin C(MMC) in 100 cases of high risk glaucoma. &&&We prospectwly studied 52 eyes of46 patients treated with MMC (Follow up 15i8.7111) and compared it with a retrospective scrie of48 eyes 01 35 patients treated with 5F...

PURPOSE To investigate the expression of chemokines and their signaling pathways after application of mitomycin C (MMC) to corneal fibroblasts. METHODS Primary porcine and human corneal fibroblasts from passages 3 to 6 were treated with MMC at concentrations of 0.05, 0.1, or 0.2 mg/mL for 1, 2, 5, or 10 minutes. The relative expression of interleukin-8 (IL-8) and monocyte chemoattractant prot...

of Purpose: A comparison of long term effect on IOP and complications trabeculectomies performed with the adjunct of either postoperative 5 fluorouracil(5FU) or peroperative mitomycin C(MMC) in 100 cases of high risk glaucoma. &&&We prospectwly studied 52 eyes of46 patients treated with MMC (Follow up 15i8.7111) and compared it with a retrospective scrie of48 eyes 01 35 patients treated with 5F...

of Purpose: A comparison of long term effect on IOP and complications trabeculectomies performed with the adjunct of either postoperative 5 fluorouracil(5FU) or peroperative mitomycin C(MMC) in 100 cases of high risk glaucoma. &&&We prospectwly studied 52 eyes of46 patients treated with MMC (Follow up 15i8.7111) and compared it with a retrospective scrie of48 eyes 01 35 patients treated with 5F...

Glucose regulatory protein (GRP58) is known to mediate mitomycin C (MMC)-induced DNA cross-linking. However, the mechanism remains elusive. We hypothesized that thioredoxin-like domains, one at NH2 terminus and another at COOH terminus, are required for GRP58-mediated MMC reductive activation leading to DNA cross-linking. Site-directed mutagenesis mutated cysteines in thioredoxin domains to ser...

OBJECTIVE To design a new controlled-release MMC-PLA film and explore whether and how this film could prevent epidural scar hyperplasia and adhesion in a post-laminectomy rat model. MATERIALS AND METHODS All procedures were performed under the approval and supervision of the Institutional Animal Care and Use Committee (IACUC) of Nanjing Medical University. A total of 120 Sprague-Dawley (SD) r...