The first organocatalyzed sulfoxidation reaction towards enantioenriched (R)-modafinil (Armodafinil®), a drug against narcolepsy, is reported here. A series of chiral organocatalysts, e.g., different chiral BINOL-phosphates, or a fructose-derived N-substituted oxazolidinone ketone (Shi catalyst) were applied for the sulfoxidation reaction with environmentally friendly H2O2 as a convenient oxyge...

1503 Background: Patients with brain cancer develop neurobehavioral dysfunction and fatigue that compromise their performance of daily activities. We report results from evaluating the efficacy and safety of modafinil treatment for tumor/therapy sequelae in this medically fragile patient population. METHODS Patients: 21-65 years old with primary malignant disease or nonmalignant cerebral tumo...

Abstract Introduction The chronic fatigue syndrome (CFS) is a heterogeneous disorder characterized by easy fatigability, feverishness, diffuse pains, and depression. Many COVID-19 patients expressed long-term effect of coronavirus (long-COVID), with some characteristics typically found in CFS. To examine the efficacy NLS-4 (Lauflumide), comparison positive control, modafinil, which has been sho...

When predicting where a target or reward will be, participants tend to choose each location commensurate with the true underlying probability (i.e., probability match). The strategy of probability matching involves independent sampling of high and low probability locations on separate trials. In contrast, models of probabilistic spatial attention hypothesize that on any given trial attention wi...

atigue is a perplexing and at times incapacitating symptom in multiple sclerosis. It has both physical and cog-nitive components and its severity is not closely related to the extent of neurologi-cal disability, nor to clinical or laboratory measures of inflammatory activity, nor to depression. 1 2 Treatment is unsatisfactory, with few controlled studies and with interpretation of results hinde...

Abstract Introduction Narcolepsy is a disorder of hypersomnolence affecting between 1:5000-1:10,000 individuals. Type 1 can be differentiated from 2 by the presence cataplexy. Visual hallucinations are reported in 50-80% T1 Narcoleptics and ~25% T2 Narcoleptics. This thought to REM-related phenomenon occurring at transitions sleep wakefulness. Auditory or paranoid delusions more rare. We report...

BACKGROUND Fatigue, cognitive deficits, and depression are frequently reported but often undertreated symptoms that can profoundly affect daily life in patients with primary brain tumors (PBTs). To evaluate the effects of the psychostimulant modafinil on fatigue, depression, health-related quality of life (HRQOL), and cognitive functioning in PBT patients, we performed a multicenter, double-bli...

Narcolepsy is a chronic neurological disease characterized by diurnal excessive sleepiness and catapleaxy. It affects 1 in every 2000 to 4000 individuals with personal, social and familiar significant repercussions. The treatment of narcolepsy is mainly based on the use of stimulants for the control of the diurnal excessive sleepiness, in conjunction with behavioral measures and sleep hygiene. ...