Four years' experience with a method for preparing a high-purity, low-fibrinogen, heat-treated factor VIII concentrate is reported. The process, batch adsorption of a cryoprecipitate extract with controlled-pore glass granules, removes 77 percent of the cryoprecipitate fibrinogen, resulting in a final concentrate-specific activity of 0.74 IU factor VIII per mg of protein at a yield of 194 IU fa...

OBJECTIVES To investigate the efficacy of a second subcutaneous dose of 6 mg sumatriptan in the treatment of recurrence of headache after successful treatment of a migraine attack with an initial 6 mg dose. METHODS In a prospective, randomised, placebo controlled, double blind, parallel group study, 803 patients were treated for one to three migraine attacks with severe or moderate headache w...

Traditional designs for phase I clinical trials assign the same dose to patients in the same cohort. In this paper, we present a new class of designs for cancer phase I trials which initially rapidly escalate by allowing multiple doses (usually 3) to be assigned to each cohort of patients. The class of designs, called the LMH-CRM (an extension of the continual reassessment method (CRM) by admin...

introduction:  skin  sparing  is  one  of  the  most  desirable  characteristics  of  high  energy  photon  beams. however, the photons emerging from the target of linacs are contaminated by secondary  electrons  as  a  result  of  their  interactions  with  air,  collimators,  flattening  filter  and  any  other  objects in their path. this phenomenon tends to increase the skin dose received b...

introduction: the aim of present study was to estimate effective dose from most common procedures performed in nuclear medicine departments of golestan province. methods: data of nuclear medicine procedures performed in 2 nuclear medicine departments in golestan province were collected during 4 years. effective dose, collective effective dose and effective dose per examination were calculated u...