نتایج جستجو برای: modified gurson model gtn
تعداد نتایج: 2310303 فیلتر نتایج به سال:
The ductile fracture of crystalline materials is a classical subject in mechanics of materials which still presents important challenges. It is driven by the process of growth and coalescence of voids and thus calls for constitutive models of the plastic response of porous crystalline materials. In this context, the consideration of the anisotropy, related to the single crystal response and the...
OBJECTIVES To evaluate the sensitivity and tolerability of shortened, glyceryl trinitrate (GTN)-potentiated, head-up tilt test (HUT) in patients older and younger than 65 with unexplained syncope and to compare the specificity of GTN-potentiated HUT (GTN-HUT) in older and younger controls. DESIGN Methodological study. SETTING Syncope units in secondary and tertiary hospitals. PARTICIPANTS...
The intergranular crack propagation of the lamellar structure β titanium alloys is investigated by using a modified Gurson-type damage model. The representative microstructure of the lamellar alloy, which consists of the soft α phase layer surrounding the hard grain interiors, is generated based on an advanced Voronoi algorithm. Both the normal fracture due to void growth and the shear fracture...
We assessed the concentration of nitroglycerin (GTN) measured in plasma at different sampling sites in the circulation during a constant i.v. infusion. Twenty patients with chronic congestive cardiac failure underwent hemodynamic monitoring during i.v. GTN infusion. Our end point was a reduction in pulmonary capillary wedge pressure by at least 25% of its control value or a 10-fold increment ov...
In the paper the effects of nucleation and growth of voids in the plastic porous media are investigated. Three different forms of the model are considered: the augmented Gurson model (total porosity model) with variable nucleation and growth material function, the same model with constant growth material function and the separated porosity model. The identification of the material functions par...
BACKGROUND Chronic therapy with nitroglycerin (GTN) results in a rapid development of nitrate tolerance which is associated with an increased production of reactive oxygen species (ROS). According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) play an important role for the devel...
it has been proposed that organic nitrates such as glyceryl trinitrate (gtn), used in the treatment of cardiovascular diseases, act by producing nitric oxide (no). however, the biochemical pathway for no formation from gtn is not well understood. in the present study, we showed that nitrate formation from gtn, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione was de...
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