A cDNA clone corresponding to a novel cGMP phosphodiesterase inhibitory subunit (PDE gamma) was isolated from a bovine retinal cDNA library using a rod PDE gamma cDNA as a probe under conditions of reduced stringency. This new clone encodes an 83-amino acid protein approximately 80% identical to rod PDE gamma. The transcript for this protein is retina specific and 940 base pairs in length. Sout...

A Personal Distributed Environment (PDE) is an example of an IP-based system architecture designed for future mobile communications. In a single PDE, there exist several Subnetworks hosting devices located across the infrastructure, which will inter-work with one another through the coordination of a Device Management Entity (DME). Some of these Sub-networks are fixed and some are mobile. In or...

This paper deals with the construction and characterization of discrete PDE splines. For this purpose, we need a PDE equation (usually an elliptic PDE), certain boundary conditions and a set of points to approximate. We give two results about the convergence of a discrete PDE spline to a function of a fixed space in two different cases: (1) when the approximation points are fixed; (2) when the ...

The basic partial differential equation PDE models for supply chain networks with re-entrant nodes and their macroscopic are proposed. However, through numerical examples, the basic continuummodels do not performwell for multiple re-entrant systems. Then, a new state equation considering the re-entrant degree of the products is introduced to improve the effectiveness of the basic continuum mode...

It is intended that this Special Session will provide a platform from which renowned specialists in Partial Differential Equations (PDE) and/or Mathematical Control Theory will present their latest research on nonlinear and evolutionary PDE. We anticipate that our speakers will have expertise in a wide-ranging array of topics, possibly including: (i) qualitative and quantitative properties enjo...

OBJECTIVE To evaluate the potential of sildenafil, vardenafil and tadalafil, all phosphodiesterase-5 (PDE-5) inhibitors used for treating erectile dysfunction, for treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). MATERIALS AND METHODS The mRNA expression of the PDE-5 was determined in rat LUT tissues. The PDE-5 inhibitors were also tested in organ-bath expe...

The study was designed to examine if the vasorelaxant effect of hydrogen sulfide was mediated by sulfhydration-associated phosphodiesterase (PDE) 5A dimerization. The thoracic aorta of rat was separated and the vasorelaxant effects were examined with in vitro vascular perfusion experiments. The dimerization and sulfhydration of PDE 5A and soluble guanylatecyclase (sGC) were measured. PDE 5A and...

Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5'-phosphate (vitamin B6 vitamers). Despite treatment, neurodevelopmental disabilities are still observed in most PDE patients underlining the need for adjunct therap...

The trace element zinc affects several aspects of immune function, such as the release of proinflammatory cytokines from monocytes. We investigated the role of cyclic nucleotide signaling in zinc inhibition of LPS-induced TNF-alpha and IL-1beta release from primary human monocytes and the monocytic cell line Mono Mac1. Zinc reversibly inhibited enzyme activity of phosphodiesterase-1 (PDE-1), PD...

Optimization problems with partial differential equation (PDE) constraints arise in many science and engineering applications. Their robust and efficient solution present many mathematical challenges and requires a tight integration of properties and structures of the underlying problem, of fast numerical PDE solvers, and of numerical nonlinear optimization. This workshop brought together exper...