The binding interaction of novel podophyllotoxin derivative, (3R,4R)-4-((benzo[d][1,3]dioxol-5-yl)methyl)-dihydro-3-(hydroxy(3,4-dimethoxyphenyl) methyl) furan-2(3H)-one (PPT), with calf thymus DNA (ctDNA) has been examined using UV-Visible absorption spectrophotometry, fluorescence spectroscopy, viscosity measurement and molecular docking studies. UV-Vis absorption results showed hyperchromic ...

Four prenylated flavonoids including isosophoranone, sophoraflavanone G, alopecurone J, alopecurone P and a resveratrol derivative HPD (2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b] furan-3,4,6-triol), were isolated from the roots of Sophora pachycarpa. The cytotoxic activity of obtained compounds was evaluated against A2780, A549, HeLa, and HCT116 human cancer cell lines. We also evaluated their his...

In this study, the lowest energy molecular structures were determined by conformational analysis of six drugs commonly used in cancer treatment, order to use as initial data for docking simulations. Using AutoDock Vina software, interaction mechanisms 6 FDA approved (Pemetrexed, Irinotecan, Tamoxifen, Gemcitabine, Topotecan and Temozolomide) with DNA investigated. addition, MM/PB(GB)SA calculat...

Myeloid leukemia 1 (MCL-1), a BCL-2 protein family member, acts as an anti-apoptotic by interacting with pro-apoptotic proteins. Its overexpression is frequently observed in numerous cancer types including breast cancer, and closely linked to the initiation progression of tumors well poor prognosis resistance therapeutic interventions. Here, database 3402 chemicals established activity against ...