نتایج جستجو برای: molecular docking studies
تعداد نتایج: 1965673 فیلتر نتایج به سال:
monoamine oxidase (ec, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. abnormal action of the monoamine oxidase b has been associated with neurological dysfunctions including parkinson´s disorder. monoamine oxidase b inhibitors divulged that these agents were effective in the therapeutic management of parkinson's disease. understanding the interaction of...
Evolutionary approaches to molecular docking typically hybridize with local search methods, more specifically, the Solis-Wet method. However, some studies indicated that local search methods might not be very helpful in the context of molecular docking. An evolutionary algorithm with proper genetic operators can perform equally well or even outperform hybrid evolutionary approaches. We show tha...
Objective(s): Hybridization of bioactive natural and synthetic compounds is one of the most promising novel approaches for the design of hit and lead compounds with new molecular structures. In this investigation, a series of novel hybrid structures bearing quinazolinone, benzofuran and imidazolium moieties were designed and synthesized. Materials and Methods:Novel hybrid compounds were prepare...
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