Matrix effects in mass spectrometry imaging (MSI) may affect the observed molecular distribution in chemical and biological systems. In this study, we use mouse brain tissue of a middle cerebral artery occlusion (MCAO) stroke model to examine matrix effects in nanospray desorption electrospray ionization MSI (nano-DESI MSI). This is achieved by normalizing the intensity of the sodium and potass...

A nuclear framework structure termed the nuclear matrix has been isolated and characterized. This matrix forms the major residual structure of isolated nuclei and consists largely of protein with smaller amounts of RNA, DNA, carbohydrate, and phospholipid. The nuclear matrix can be further resolved by combined treatment with DNase and RNase. The remaining nuclear protein structure, after extrac...

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset progression. However, these relationships depend on both the biochemical molecular association between cells their extracellular matrix, as well biophysical mechanical properties orchestrated by cytoskeletal, membrane matrix components. To fully appreciate role of cell when determining n...

The ab initio atom-centered density matrix propagation (ADMP) and the quantum wavepacket ab initio molecular dynamics (QWAIMD) computational methods are briefly described. Studies on vibrational and electronic properties obtained utilizing these methods are highlighted. ∗ [email protected]

Front Cover: The effects of 4010NA content on the damping and aging properties hydrogenated nitrile butadiene rubber (HNBR)/nitrile (NBR) matrix are studied via molecular simulation experiments. With an increase in content, there is a decrease free volume fraction (FFV), attributed to hydrogen bond network between HNBR/NBR matrix. This reported by Meng Song, Qi Qin, co-workers article number 22...

This study concerns the genetic diversity and taxonomic status of Marrubium species from central and south-west of Zagros region, Iran. It is investigated by Inter-Simple Sequence Repeat analysis. A total of 68 accessions from five Marrubium species were collected from their natural habitats. Molecular analysis was approved with 17 primers, of which 12 were carried out in the reaction mixture. ...

analysis of time series data can involve the inversion of large covariance matrices. for theclass of arma (p, q) processes there are no exact explicit expressions for these inverses, except for thema (1) process. in practice, the sample covariance matrix can be very large and inversion can becomputationally time consuming and so approximate explicit expressions for the inverse are desirable.thi...

PURPOSE We have previously reported that matrix metalloproteinases MMP-2, MMP-9, and the complex MMP-9/NGAL can be detected in urine of patients with a variety of cancers including prostate and bladder carcinoma. In addition, we also detected several unidentified urinary gelatinase activities with molecular weights >125 kDa. The objective of the current study was to identify these high molecula...

CP2K is a freely available atomistic and molecular simulation code, able to study of a wide range of molecular and bulk materials with methods including classical potentials, density functional theory (DFT), Hartree-Fock and post-HF methods. Following two earlier dCSE projects, we report here on an additional 6 months of work to optimisise the DBCSR sparse matrix multiplication library embedded...