cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

It has been reported (1) that epinephrine, norepinephrine, and serotonin stimulate the oxidation of the first but not the sixth carbon atoms of glucose by beef anterior pituitary slices and rat cerebral cortical fragments. It is shown here that this effect on glucose oxidation is also exerted by other amines which are substrates of monoamine oxidase and that inhibitors of monoamine oxidase bloc...

Mitochondrial monoamine oxidase was inactivated with 2-[2-’4C]phenylcyclopropylamine, dialyzed, and treated with acidic 2,4-dinitrophenylhydrazine. Contrary to the report of Paech et al. (Paech, C., Salach, J. I., and Singer, T. P. (1980) J. Biol. Chern. 255, 2700-2704), the 2,4-dinitrophenylhydrazone obtained was not that of 2-phenylcyclopropanone, but rather of cinnamaldehyde. Futhermore, den...

The distribution of catechol-O-methyl transferase and monoamine oxidase activity in the ocular tissues of albino rabbits has been determined with a radioactive tracer assay. The distribution of the former varied in the different tissues within a restricted range whereas the distribution of monoamine oxidase activity exhibited larger variations. Sympathetic denervation did not appear to affect c...

Mitochondrial monoamine oxidase was inactivated with 2-[2-14C]phenylcyclopropylamine, dialyzed, and treated with acidic 2,4-dinitrophenylhydrazine. Contrary to the report of Paech et al. (Paech, C., Salach, J. I., and Singer, T. P. (1980) J. Biol. Chem. 255, 2700-2704), the 2,4-dinitrophenylhydrazone obtained was not that of 2-phenylcyclopropanone, but rather of cinnamaldehyde. Furthermore, den...

Monoamine oxidase (EC 1.4.3.4) exists in at least two forms (termed type A and type B) with different substrate and inhibitor specificities (Johnston, 1968; Knoll & Magyar, 1972). Amine neurotransmitters are among a wide range of substrates (Blaschko, 1974) and abnormalities of monoamine oxidase activity may therefore contribute to neurological disease. Most studies of such diseases have looked...

Plateiet monoamine ox!dase (MAO) activity was determined, using benzylainine as substract. Results are expressed as nM benzaidehyde/nig protein hour, at 37. A total of 79 diabetics (40 M and 39 F) ranging in age from 3 to 70 years was stud,ed. A normal control group inciuded 39 persons (17 M and 22 F) ranging in age from 16 to 60 years. Piatelet MAO activity shows a slight variation in relation...

The aim of the present experiments was to clarify the influence of chlorpromazine on 5-hydroxytryptamine (5HT) in mouse brain. It was shown earlier (Bartlet, 1960) that the injection of iproniazid into mice produced an accumulation of cerebral 5HT, and that the rate of accumulation of the amine was reduced by chlorpromazine. It was suggested that chlorpromazine reduced the rate of formation of ...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...