RATIONALE Intra-sarcoplasmic reticulum (SR) free [Ca] ([Ca](SR)) provides the driving force for SR Ca release and is a key regulator of SR Ca release channel gating during normal SR Ca release or arrhythmogenic spontaneous Ca release events. However, little is known about [Ca](SR) spatiotemporal dynamics. OBJECTIVE To directly measure local [Ca](SR) with subsarcomeric spatiotemporal resolutio...

PURPOSE Studies have both supported and refuted the concept that it is the intent to perform ballistic contractions that determines velocity-specific gains in resistance training. The purpose of this investigation was to determine whether ballistic intent is as effective as ballistic movement in improving muscle activation, force, movement time, and reaction time. METHODS Subjects completed 8...

Parkinson's disease is a progressive neurodegenerative characterized by tremors and bradykinesia (slowing of movement speed) all due to the loss dopamine levels in brain. The containing neurons brain becomes affects different parts Dopamine essential as enables communicate control movement, which lacking with Parkinson’s Disease. In Parkinson’s, are vulnerable degeneration because its extensive...

A loud auditory stimulus (LAS) presented during movement preparation can result in an earlier than normal movement onset. This effect had initially been assumed to be independent of the sensorial modality people attended to trigger their responses. In 2 experiments, we tested whether this assumption was warranted. In Experiment 1, we employed a timed response paradigm in which participants were...

Rabbit neutrophils were stimulated with the chemotactic peptide fMet-Leu-Phe in the presence of the methyltransferase inhibitors homocysteine (HCYS) and 3-deazaadenosine (3-DZA) . HCYS and 3-DZA inhibited chemotaxis, phospholipid methylation, and protein carboxymethylation in a dose-dependent manner . The chemotactic peptide-stimulated release of [t "C]arachidonic acid previously incorporated i...

Rabbit neutrophils were stimulated with the chemotactic peptide fMet-Leu-Phe in the presence of the methyltransferase inhibitors homocysteine (HCYS) and 3-deazaadenosine (3-DZA) . HCYS and 3-DZA inhibited chemotaxis, phospholipid methylation, and protein carboxymethylation in a dose-dependent manner . The chemotactic peptide-stimulated release of [t "C]arachidonic acid previously incorporated i...

The hammer throw is an event in which a competitor tries to throw the hammer, a 16-pound (7.26 kg) ball attached to a handle with a length of piano wire (a length of 117.5 to 121.5 cm from ball to the inside of the handle), as far as possible within an arc of 35° from a concrete circle with a diameter of 2.13 m, combining a rotational movement with a translational movement. It is possible to sa...