OBJECTIVE Methylphenidate (MPH) is a prescription stimulant drug with known abuse potential; however, little is known about its patterns of misuse or the characteristics of its abusers. METHODS A sample of 50 university students reporting MPH misuse and 50 control subjects matched for age, sex, and ethnicity completed structured face-to-face interviews about their MPH and other drug use. For ...

The postulate that twice the mg/kg dose of dl-methylphenidate (dl-MPH) would result in equal exposure to d-MPH when compared to half that mg/kg dose of the chiral switch product dexmethylphenidate (d-MPH) was tested. Using a randomized, crossover study design, 12 men and 12 women received either immediate-release (IR) dl-MPH (0.3 mg/kg) or IR d-MPH (0.15 mg/kg). Relative bioavailability compari...

Effects of methylphenidate (MPH), a therapeutic agent used in children presenting the attention deficit hyperactivity disorder (ADHD), on the membrane potential and current in neurons of the rat locus coeruleus (LC) were examined using intracellular and whole cell patch-clamp recording techniques. Application of MPH (30 microM) to artificial cerebrospinal fluid (ACSF) produced a hyperpolarizing...

Bradley J. McCall MBBS,MPH,MA, FAFPHM, Public Health Physician, Adjunct Professor (UQ) Megan K. Young MBBS, MPH, FAFPHM, Public Health Physician, Lecturer Scott Cameron MD, MPH, FAFPHM, Clinical Associate Professor Rod Givney BA, BSc(Med)(Hons), MBBS, FRCPA, PhD, MPH, Senior Staff Specialist, Conjoint Senior Lecturer Robert Hall BSc(Med), MBBS, MPH, GCHE, DipRACOG, FRACMA, FAFPHM, FPHAA, Senior...

Affiliations: Institute of Tropical Medicine, Department of Public Health, Antwerp, Belgium (W Van Damme, MD, MPH, K Hermann, MA, MPH); School of Public Health, Makerere University, Kampala, Uganda (GW Pariyo, MBChB, PhD); Department of HIV and AIDS, Ministry of Health, Lilongwe, Malawi; Management Sciences for Health, Lilongwe, Malawi (EJ Schouten, MD, MPH); Federal HIV/AIDS Prevention and Con...

Matthew A. Davis, MPH, PhD; Benjamin Y. Cher, MS; Christopher R. Friese, RN, Julie P. W. Bynum, MD, MPH

Darpun D. Sachdev, MD; Hannah K. Brosnan, MPH; Michael J. A. Reid, MD, Michelle Kirian, Stephanie E. Cohen, Trang Q. Nguyen, PhD, Susan Scheer, MPH