BACKGROUND AND PURPOSE Better measures of cerebral tissue perfusion and earlier detection of ischemic injury are needed to guide therapy in subarachnoid hemorrhage (SAH) patients with vasospasm. We sought to identify tissue ischemia and early ischemic injury with combined diffusion-weighted (DW) and hemodynamically weighted (HW) MRI in patients with vasospasm after SAH. METHODS Combined DW an...

BACKGROUND AND OBJECTIVE Cerebral microembolism detected by transcranial Doppler (TCD) occurs systematically during cardiac catheterization, but its clinical relevance, remains unknown. Studies suggest that asymptomatic embolic cerebral infarction detectable by diffusion-weighted (DW) MRI might exist after percutaneous cardiac interventions with a frequency as high as 15 to 22% of cases. We hav...

OBJECTIVES Diffusion-weighted magnetic resonance imaging (DW-MRI) and imaging of glucose metabolism by positron emission tomography (FDG-PET) provide quantitative information on tissue characteristics. Combining the two methods might provide novel insights into tumor heterogeneity and biology. Here, we present a solution to analyze and visualize the relationship between the apparent diffusion c...

OBJECTIVES This study sought to randomly compare cerebral protection with ANGIOGUARD (Cordis Corporation, Bridgewater, New Jersey) with Mo.Ma (Invatec/Medtronic Vascular Inc, Santa Rosa, California) during carotid artery stenting (CAS), using diffusion-weighted magnetic resonance imaging (DW-MRI) to detect new ischemic cerebral lesions. The number, size, and location of lesions were analyzed. ...

We present a new method for the uncertainty estimation of diffusion parameters for quantitative body DW-MRI assessment. Diffusion parameters uncertainty estimation from DW-MRI is necessary for clinical applications that use these parameters to assess pathology. However, uncertainty estimation using traditional techniques requires repeated acquisitions, which is undesirable in routine clinical u...

Introduction: It has been suggested that heavily diffusion-weighted (DW) functional MRI (fMRI) signal changes originate from water in a slow diffusion phase and reflect neuronal activity via cell-swelling [1]. However, several investigations comparing signal changes during visual stimulation and hypercapnia have not arrived at any conclusive agreement on the signal source [2-4]. The role of the...

The foundation for an accurate and unifying Fourier-based theory of diffusion weighted magnetic resonance imaging (DW-MRI) is constructed by carefully re-examining the first principles of DW-MRI signal formation and deriving its mathematical model from scratch. The derivations are specifically obtained for DW-MRI signal by including all of its elements (e.g., imaging gradients) using complex va...

There is an increasing awareness that the evaluation of tumor response to oncologic treatments based solely on anatomic imaging assessments face many limitations, particularly in this era of novel biologic targeted therapies. Functional imaging techniques such as diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) have the ability to depict important tum...

PURPOSE To evaluate diffusion weighted MRI (DW-MR) as a response metric for assessment of neoadjuvant chemotherapy (NAC) in patients with primary breast cancer using prospective multi-center trials which provided MR scans along with clinical outcome information. MATERIALS AND METHODS A total of 39 patients with locally advanced breast cancer accrued from three different prospective clinical t...

ObjectiveFew data exist concerning the rate of silent cerebral ischaemic events following endovascular treatment aortic arch. The objective this work was to quantify these lesions using STEP registry (NCT04489277).MethodsThis multicentre retrospective cohort study included consecutive patients treated with an endoprosthesis deployed in Ishimaru zone 0–3 and brain diffusion weighted magnetic res...