Introduction: The aim of this study was to characterize the chemical composition and antimicrobial activity of Trachyspermum copticum essential oil (EO). Methods: The chemical composition of seed samples obtained from Mianeh city in East Azerbaijan, was assessed using gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity was evaluated by disc diffusion method against methicil...

Baseline methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with nosocomial and community-acquired pneumonia collected during Phase 3 trials for ceftobiprole were characterized. Eighty-four unique isolates from patients enrolled in Europe (50.0%), Asia-Western Pacific region (APAC; 20.2%), North America (19.0%), Latin America (8.3%), and South Africa (2.4%) were included....

OBJECTIVES The antimicrobial efficacy of an iodine-impregnated incise drape against MRSA was evaluated in a skin model. The permeation of iodine from this drape into the skin was also assessed. METHODS The antimicrobial efficacy was evaluated in ex vivo studies following application of the surgical incise drape for various times on the surface of donor skin, which was inoculated with either 1...

Objective: In traditional medicine, the Pulicaria species are used for various disorders such as inflamed wounds, skin diseases, and bronchitis. This study investigated antibacterial effect of five in Turkey; (Pulicaria (P) arabica (L.) Cass., P. dysenterica Bernh., odora Reichb., sicula Moris, vulgaris Gaertn.) against certain significant pathogenic gram-negative gram-positive reference bacter...

This study is to determine the antibacterial efficacy of Lawsonia inermis against methicillin-resistant Staphylococcus aureus (MRSA) which has become a leading cause infections. The leaves also known as Henna or lalley leave were subjected extraction with seventy percent (70%) methanol using cold maceration technique after phytochemical screening and partitioning carried out following standard ...

Gallium is a trivalent semi-metallic element that has shown antimicrobial activity against several important human pathogens. This antimicrobial activity is likely related to its substitution in important iron-dependent pathways of bacteria. The genus Staphylococcus, which includes human and animal pathogens that cause significant morbidity and mortality, requires iron for growth and colonizati...

Vancomycin is considered the goldstandard treatment for infections caused by methicillin-resistant Staphylococcus aureus (MRSA). In recent years, reduced susceptibility of S. aureus to vancomycin has emerged. This problem seems to be based on the increased use of vancomycin, with characteristic poor tissue penetration, slow bactericidal activity and risk of nephrotoxicity resulting lack of elim...

Bacterial infections are a constant challenge in the management of acute and chronic wounds. Chronic wounds, such as diabetic foot ulcers, have increased significantly last few years due to rise an aging population. A better understanding infectious pathophysiological mechanisms is urgently needed along with new options for treatment wound wound-healing disorders. New advances preparation bioco...

Infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus (MRSA) with reduced susceptibility to vancomycin and daptomycin has few adequate therapeutic options. Ceftaroline (CPT) is bactericidal against daptomycin (DAP)-nonsusceptible (DNS) and vancomycin-intermediate MRSA, but supporting data are limited for IE. This study evaluated the activities of ceftaroline, vancomy...

INTRODUCTION Ceftaroline is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA) that was recently launched in Singapore. It received approval from the United States (US) Food Drug Administration (FDA) and European Commission for the treatment of adult patients with community-acquired pneumonia (CAP) and complicated skin and soft tissue infec...