Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation, glycosylation, and disulfide linkage formation, which generate mature POMC-derived peptides. Therefore, POMC is a useful model for the investi...

The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neurointermediate lobes (NILs). Immunoneutralization of MCH in tilapia NILs further...

Glutamate excitotoxicity is a common pathology to blinding ischemic retinopathies, such as diabetic retinopathy, glaucoma, and central retinal vein or artery occlusion. The development of an effective interventional modality to glutamate excitotoxicity is hence important to preventing blindness. Herein we showed that α-melanocyte-stimulating hormone (α-MSH) time-dependently protected against gl...

The central melanocortin system is critical in the regulation of appetite and body weight, and leptin exerts its anorexigenic actions partly by increasing hypothalamic proopiomelanocortin (POMC) expression. The POMC-derived peptide -melanocytestimulating hormone ( MSH) is a melanocortin 4 receptor agonist, and its potency in reducing energy intake is strongly increased by N-acetylation. The rea...

Combined acute renal and pulmonary failure has a very high mortality. In animals, lung injury develops after shock or visceral or renal ischemia. Alpha-melanocyte-stimulating hormone (alpha-MSH) is an antiinflammatory cytokine, which inhibits inflammatory, apoptotic, and cytotoxic pathways implicated in acute renal injury. We sought to determine if alpha-MSH inhibits acute lung injury after ren...

Inflammatory processes contribute to neurodegenerative disease, stroke, encephalitis, and other central nervous system (CNS) disorders. Activated microglia are a source of cytokines and other inflammatory agents within the CNS and it is therefore important to control glial function in order to preserve neural cells. Melanocortin peptides are pro-opiomelanocortin-derived amino acid sequences tha...

BACKGROUND Objectively assessed physical performance is a strong predictor for morbidity and premature death and there is an increasing interest in the role of sarcopenia in many chronic diseases. There is a need for robust and valid functional tests in clinical practice. Therefore, the repeatability and validity of a newly developed maximal step up test (MST) was assessed. METHODS The MST, a...

BACKGROUND Alpha-melanocyte-stimulating-hormone (α-MSH) has marked anti-inflammatory potential. Proinflammatory cytokines are critical mediators of the disturbed cartilage homeostasis in osteoarthritis, inhibiting anabolic activities and increasing catabolic activities in chondrocytes. Since human chondrocytes express α-MSH receptors, we evaluated the role of the peptide in modulating chondrocy...

In this study low-grade magnesium oxide (MgO) produced by calcinations of natural magnesite was used in mine water treatment using a laboratory-column device. The from the abandoned Osor (NE Spain) with MgO showed removal metals both and tailing leachates. PHREEQC numerical code Geochemist’s Workbench (GWB) were to evaluate speciation dissolved constituents calculate saturation state effluents....

Sabatier, Nancy, and Gareth Leng. Presynaptic actions of endocannabinoids mediate -MSH-induced inhibition of oxytocin cells. Am J Physiol Regul Integr Comp Physiol 290: R577–R584, 2006. First published November 3, 2005; doi:10.1152/ajpregu.00667.2005.—We recently showed that central injections of -melanocyte-stimulating hormone ( -MSH) inhibits oxytocin cells and reduces peripheral release of o...