Dnmt1 is frequently overexpressed in cancers, which contributes significantly to cancer-associated epigenetic silencing of tumor suppressor genes. However, the mechanism of Dnmt1 overexpression remains elusive. Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1 (MTF-1). Zinc treatme...

Three different techniques were used to determine the Modulation Transfer Function (MTF) of a 35mm film scanner. The first involved scanning sine wave charts comprising a number of patches with different frequencies of known modulation. The second method involved the scanning and Fourier transform of a photographic grain noise pattern to simulate low modulation white noise. Finally, the ISO 122...

Abstract. Mesoscale ocean processes are prevalent in many parts of the global oceans and may contribute substantially to meridional movement heat. Yet earlier surveys temperature fluxes heat transport (HT) have not formally distinguished between mesoscale large-scale contributions, or they defined eddy contributions based on temporal rather than spatial characteristics. This work uses filtering...

OBJECTIVE The study aimed to examine the epidemiology of hypertonic contractures and its relationship with minimal trauma fracture (MTF), and to determine the incidence and predictors of (MTF) in long-term care residents. DESIGN This was a longitudinal cohort study of prospectively collected data. Participants were followed from March 2007 to March 2016 or until death. SETTING A 300-bed lon...

PURPOSE To investigate the effect of various presbyopic vision corrections on nighttime driving performance on a closed-road driving circuit. METHODS Participants were 11 presbyopes (mean age, 57.3+/-5.8 years), with a mean best sphere distance refractive error of R+0.23+/-1.53 DS and L+0.20+/-1.50 DS, whose only experience of wearing presbyopic vision correction was reading spectacles. The s...

BACKGROUND Different target-filter combinations in computed radiography have different impacts on the dose and image quality in digital radiography. This study aims to evaluate the mean glandular dose (MGD) and modulation transfer function (MTF) of various target-filter combinations by investigating the signal intensities of X-ray beams. METHODS General Electric (GE) Senographe DMR Plus mammo...

PURPOSE Sufentanil, a lipophilic opioid, is used to provide analgesia for labour and Caesarean section, but may cause neonatal depression. Factors affecting placental transfer of sufentanil were investigated using human placentas. STUDY DESIGN Transfer and uptake of sufentanil by the human placenta were studied using a single pass (open) in vitro perfusion model. The effects of change in sufe...