Mucociliary clearance and fluid transport along epithelial surfaces are carried out by multiciliated cells (MCCs). Recently, human mutations in Cyclin O (CCNO) were linked to severe airway disease. Here, we show that Ccno expression is restricted to MCCs and the genetic deletion of Ccno in mouse leads to reduced numbers of multiple motile cilia and characteristic phenotypes of MCC dysfunction i...

Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination o...

Disease processes can impair ciliary function, alter secretion production and mucus rheology, and interfere with the cough reflex. Airway clearance therapy has been a cornerstone of therapy aimed at minimizing the devastating effects of airway obstruction, infection, and inflammation due to mucus stasis on the conducting airways and lung parenchyma. Although challenges to performing clinical st...

Mucociliary clearance (MCC), a vital key defense mechanism is especially important in the upper airways and sinuses, as it protects the body against noxious inhaled materials [1]. The removal of debris-laden mucus in the sinuses completely depends on MCC, whereas in the lower airways, MCC can be compensated for by other mechanisms like coughing [2]. The nasal mucociliary clearance (NMC) system ...

THE mucociliary apparatus is the main defense mechanism preventing respiratory infection, removing inhaled debris and pathogens from the airways. Many critical care patients suffer from ciliary loss, reduced cilia beat frequency, and mucus clearance, which may be related to the high incidence of nosocomial respiratory infections within intensive care. It is often necessary to use an increased f...

The concerted movement of cilia propels inhaled contaminants out of the lungs, safeguarding the respiratory system from toxins, pathogens, pollutants, and allergens. Motile cilia on the multiciliated cells (MCCs) of the airway epithelium are physically oriented along the tissue axis for directional motility, which depends on the planar cell polarity (PCP) signaling pathway. The MCCs of the mous...

The effects of intracameral injection of hydrogen peroxide were examined using different techniques in young (4 to 6 weeks of age, =500 g) and adult (3 to 6 months of age, 2.5 to 3.5 kg) rabbits. A response occurred that included changes in intraocular pressure, increased permeability of the iris vasculature, and swelling of the ciliary processes. The initial fall in intraocular pressure was th...