The title compounds, rac-(1'R,2R)-tert-butyl 2-(1'-hydroxyethyl)-3-(2-nitrophenyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate, C(17)H(20)N(2)O(6), (I), rac-(1'S,2R)-tert-butyl 2-[1'-hydroxy-3'-(methoxycarbonyl)propyl]-3-(2-nitrophenyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate, C(20)H(24)N(2)O(8), (II), and rac-(1'S,2R)-tert-butyl 2-(4'-bromo-1'-hydroxybutyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-car...

Chiral nitrogen-containing compounds are widely distributed in nature and include many biologically important molecules (Chart 1). In these compounds, the nitrogen-containing units are known to play important roles for their bioactivities. For the synthesis of these chiral nitrogen-containing building blocks, use of imines as electrophiles is the most promising and convenient route.1 While many...

Non-precious metal Fe–N/C heterogeneous catalysts efficiently catalyse epoxidation at 25 °C and atmospheric pressure using oxygen as oxidant. The reaction is studied on-line consumption, electrochemistry, UV-vis spectroscopy.

tropane alkaloids, and consequently there is an increasing interest in their potential pharmaceutical use, particularly against cocaine abuse. Compelled by the interesting biological activities of 8oxatropanes, many groups have embarked on the search for new methodologies to construct this bicyclic structure. For example, Molander and co-workers have reported a Lewis acid promoted double allyla...

Mukaiyama aldol and the Nobel prize winning Sharpless epoxidation, titanium(IV) reveals its utility once again in a recent contribution from the group of Professor Salvatore D. Lepore from the Florida Atlantic University, Boca Raton (USA) on stereoretentive and chemoselective halogenations and azidations of hindered secondary sulfonates. “For the first time,” said Professor Lepore, “alcohols as...

Intermolecular hydroamination or hydroarylation reactions of norbornene and cyclohexadiene performed with catalytic amounts of Brönsted or Lewis acid in ionic liquids were found to provide higher selectivity and yields than those performed in classical organic solvents. The ionic liquid increases the acidity of the media and stabilizes ionic intermediates through the formation of supramolecular...

The development of new reactions is important to improve the toolbox organic chemistry. One way nudge a reaction undergo pathway different from what it normally takes. Stereoinvertive SN2 known be intolerant bulky tertiary carbon centers, which tend proceed through SN1 pathways form racemized products. This leads long-standing challenge in synthesis; that is, how prepare enantiopure compounds s...