The multicomponent reaction of 1,2-di(4-pyridyl)ethylene, catechol, 3,5-bis(trifluoromethyl)phenylboronic acid and 1,5-dinaphtho-38-crown-10 or bis-para-phenylene-34-crown-10, respectively, resulted in the formation of rotaxanes, which were characterized by X-ray crystallography.

We discovered a novel organocatalysed multicomponent domino Knoevenagel-aza-Michael-cyclocondensation reaction leading to an unprecedented straightforward synthesis of 1,5-diazabicyclo[3.3.0]octane-2,6-diones. The specific capability of the (DHQ)2PHAL organocatalyst in this process was also highlighted to eventually furnish the corresponding bicyclopyrazolidinones with up to 96 : 4 er.

The relative rates of the aldol reaction catalyzed by supported primary and secondary amines can be inverted by 2 orders of magnitude, depending on the use of hexane or water as a solvent. Our analyses suggest that this dramatic shift in the catalytic behavior of the supported amines does not involve differences in reaction mechanism, but is caused by activation of imine to enamine equilibria a...

A novel multicomponent reaction allowing for a one-pot formation of three carbon-carbon bonds has been developed. It is based on in situ generation and anionic dimerization of methylenedithiane and produces a versatile synthetic equivalent of 4-hydroxy-1,3-alkanediones which, among other things, offers expeditious one-pot access to 3(2H)-furanones.

The multicomponent synthesis of α,β-disubstituted N-sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an organocobalt as the initiator of a Mannich-like process.

The paper presents an application of the asymmetry approach to spirooxindoles via Brevicolline, Cinchonidine or Cinchonine catalyzed one-pot multicomponent synthesis. Brevicolline, in comparison with Cinchonidine or Cinchonine, catalyzes the reaction of isatins, acetylacetone/ethyl 3-oxobutanoate and malononitrile, with the formation of spiro[oxindole-3,4'-4'H-pirane] derivatives in an opticall...

The temperature dependent selectivity switch in the reaction of arynes with aliphatic alcohols in THF has been reported. At -20 °C, arynes smoothly insert into the O-H bond of alcohols to form alkyl aryl ethers. Interestingly, at 60 °C, a highly selective multicomponent coupling occurs with the solvent THF acting as the nucleophilic trigger affording (4-(alkoxy)butoxy)arenes.

A novel multicomponent synthesis of ketene dithioacetal rhodanines has been reported by reactions of primary amine, carbon disulfide, ethyl chloroacetate, and alkyl halide in DMF. The catalytic effects of different bases have been investigated and potassium carbonate can efficiently catalyze the reaction in moderate to good yields at room temperature. 2013 Elsevier Ltd. All rights reserved. Mul...

sulfated titania nanoparticles (so42-/tio2 nps) were synthesized using titanium tetraisopropoxide (ttip) by the sol-gel method. the structure and morphology of the prepared nanocatalyst was characterized using x-ray diffraction (xrd), scanning electron microscopy (sem) and brunauer–emmett–teller (bet) methods as well as fourier transform infrared (ft-ir) and energy dispersive x-ray (edx) spectr...