Previously considered benign, Plasmodium vivax malaria infection is now increasingly being recognised as a cause of severe and complicated malaria1. We present a case of an 11-yr-old male child, who developed multiple organ dysfunction in the form of oliguric acute renal failure, hepatitis, gastrointestinal bleeding with shock, bacterial peritonitis along with severe anaemia and thrombo cytopen...

hydatid disease is the most common infections worldwide, but it rarely involves multiple organs. herein, a 12-year-old boy is presented, who was admitted to children's medical center, tehran university of medical sciences, tehran, iran with symptoms of irritability, sleepless, and weak­ness of the extremities. patient's brain computed tomography (ct) scan with contrast media showed large multil...

BACKGROUND Cell-free DNA concentrations increase in the circulation of patients after trauma and may have prognostic potential, but little is know concerning the temporal changes or clearance of the DNA or its relationships with posttraumatic complications. We investigated temporal changes in plasma DNA concentrations in patients after trauma with use of real-time quantitative PCR. METHODS Se...

OBJECTIVE To evaluate the role of complement factor C5 in a model of zymosan-induced multiple organ dysfunction syndrome. DESIGN Experimental animal study. SETTING Central animal laboratory of a university hospital. SUBJECTS Twenty-five C5-deficient B2D10/Old and 25 C5-sufficient B2D10/New mice. INTERVENTIONS On day 0, all mice received an intraperitoneal injection with zymosan suspende...

Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several org...

Shock is a life-threatening pathophysiologic state referring to inadequate organ perfusion, which can progress end-organ dysfunction and eventually, multiple failure death. The diagnosis of shock clinical, necessitating good understanding the underlying etiology, pathophysiology, as well biochemical, hemodynamic manifestations various presentations shock. This article describes an approach shoc...

Leptospirosis is a re-emerging infectious disease affecting both animals and humans worldwide. This infection is associated with occupational contact with animals, recreational exposure and contact with leptospires as a consequence of flooding. Multiple organ involvement may be encountered in acute severe leptospirosis and early renal involvement is commonly characterized by tubulo-interstitial...

Largest of all endocrine glands, the Thyroid, is a butterfly shaped organ, located in anterior neck, extending from C5 to T1. Normal Balance its hormones are vital, as they play key role many vital processes, especially metabolism. Hyperthyroidism condition which there rise TSH hormone levels, due multiple factors, causing multi-organ dysfunction. Its prevalence about 20:1000 females. Males aff...

We conducted a prospective study to identify the children having multiple organ dysfunction at admission using the PELOD score, and its impact on the mortality in a pediatric intensive care unit of a tertiary care hospital in north India over a 13 month period. Data were collected in a predesigned collection sheet and the PELOD score was calculated. 209 patients were admitted. In 37.2% primary ...

INTRODUCTION Transfusion is a common treatment in pediatric intensive care units (PICUs). Studies in adults suggest that prolonged storage of red blood cell units is associated with worse clinical outcome. No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill c...