Cell therapy is increasingly recognized as a beneficial practice in various cardiac conditions, but its fundamentals remain largely unclear. The fates of transplanted multipotent stromal cells in postinfarction cardiac microenvironments are particularly understudied. To address this issue, labeled multipotent stromal cells were infused into rat myocardium at day 30 after myocardial infarction, ...

Growth factor independent 1 (Gfi1) is a transcriptional repressor originally identified as a gene activated in T-cell leukemias induced by Moloney-murine-leukemia virus infection. Notch1 is a transmembrane receptor that is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL). Gfi1 is an important factor in the initiation and maintenance of lymphoid leukemias and its deficienc...

Cell fate decisions in metazoans are regulated by Notch signals. During lymphoid development, Notch influences a series of cell fate decisions involving multipotent progenitors. This review focuses on current views and lingering uncertainties about Notch function in lymphoid cells.

Background Theca cells play important roles during folliculogenesis. They synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle to produce a mature and fertilizable oocyte. In children patients who are going to be ovariectomy, follicogenesis is at early stage and thus the follicles need to be mature in...

Extracellular signals that can influence the fate of multipotent progenitor cells have been described in recent studies of the vertebrate nervous system, emphasizing the contribution of instructive mechanisms to the generation of cellular diversity.

SUMMARY: Multipotent mesenchymal stromal cells (MSC) are under consideration for the treatment of autoimmune disease (AD) based on their in vitro antiproliferative properties, efficacy in animal models, apparent low acute toxicity, and the early positive anecdotal outcomes in human acute graft versus host disease. Phase I/II clinical trials are under way in multiple sclerosis and Crohn's diseas...

Multipotent mesenchymal stromal cells (MSCs) are actively involved in reparation and inflammation processes, providing damaged tissue suppressing immune cell responses vivo. The effects mostly due to the production of a wide range paracrine factors, including growth factors immunomodulatory mediators. To induce immunosuppressive activity, MSCs primed by inflammatory cytokines, which results an ...

The biliary tree system consists of two divisions: intrahepatic bile ducts and extrahepatic bile ducts. The development of the biliary tree, and secondarily the liver, shares a common origin with ventral pancreas. A common progenitor for liver, biliary duct system, and ventral pancreas exists at early stages of development, when the anterior definitive endoderm is forming the foregut. Several s...

recent findings in stem cell biology have opened a new window in regenerative medicine. the endometrium possesses mesenchymal stem cells (mscs) called endometrial stem cells (enscs) having specific regenerative properties linked to adult stem cells. they contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. many clinical trials were undertaken to asce...