OBJECTIVE Methylmalonic acidura (MMA) is a rare autosomal recessive inborn error of metabolism. In this study we present a novel nucleotide change in the mutase (MUT) gene of two unrelated Iranian pedigrees and introduce the methods used for its functional analysis. MATERIALS AND METHODS Two probands with definite diagnosis of MMA and a common novel variant in the MUT were included in a descr...

Plant height (PH) is a complex trait regulated by the environment and multiple genes. PH directly affects crop yield, harvest index, lodging resistance. From plant dwarf mutants, many genes related to have been identified described. Nonetheless, molecular mechanism of regulation in high-culm rice mutants has not well studied. By using transcriptome weighted gene co-expression network analysis (...

BACKGROUND Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root. METHODS We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC MIN/+ (APCMIN) mouse...

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