CONTEXT Cutaneous T-cell lymphomas such as mycosis fungoides are uncommon neoplasms with a long and often relatively indolent course. Some eventually metastasize to lymph nodes or visceral organs but there are to our knowledge only two prior reports which describe clinically relevant pancreas involvement. CASE REPORT We present the case of a 52-year-old man with mycosis fungoides who develope...

CTCL: cutaneous T-cell lymphoma CTLA4: cytotoxic T-lymphocyte antigen-4 MF: mycosis fungoides INTRODUCTION Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL). Immunostimulatory approaches, such as interferon administration, are well established in the treatment of CTCL. In the last years, several new antibodies that enhance the immune system activity have entered...

The gene encoding the beta-chain of the T-cell antigen receptor (TCR) has been analyzed for evidence of rearrangement in skin, blood, and lymph node specimens from 23 cases of known or suspected cutaneous T-cell lymphoma (CTCL). Two cutaneous large cell lymphomas, 4 cases of Sézary syndrome, and 5 cases of advanced (tumor) stages of mycosis fungoides showed clonal rearrangement of the TCR beta-...

Vol. 30, No. 1, 2018 95 Received November 29, 2016, Revised December 19, 2016, Accepted for publication December 23, 2016 Corresponding author: Weon Ju Lee, Department of Dermatology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea. Tel: 82-53-420-5838, Fax: 82-53-426-0770, E-mail: [email protected] This is an Open Access article distributed under the terms o...

BACKGROUND Mycosis fungoides and Sézary syndrome are cutaneous T-cell lymphomas characterized by the epidermotropism of tumor cells. Neuropathic disease is rare during mycosis fungoides and Sézary syndrome and usually results from a central nervous system involvement in late stages. Neurolymphomatosis is defined as the infiltration of the peripheral nerves by tumor lymphocytes. It has been desc...

Mycosis fungoides and Sézary syndrome are the most common of the cutaneous T-cell lymphomas, which are a heterogeneous group of neoplasms that affect the skin as a primary site. Although the aetiologies of mycosis fungoides and Sézary syndrome are unknown, important insights have been gained in the immunological and genetic perturbations that are associated with these diseases. Unlike some B-ce...