Both angiotensin receptor antagonists and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have been shown to attenuate cardiomyocyte hypertrophy after myocardial infarction. Whether combination treatment may be superior to either drug alone on cardiomyocyte hypertrophy remains unclear. After ligation of the left anterior descending artery, rats were randomized to both, one,...

There is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (g...

Estrogen regulation of myocardial chymase and chymase effects on cardiac remodeling are unknown. To test the hypothesis that estrogen prevents pressure overload-induced adverse cardiac remodeling by inhibiting mast cell (MC) chymase release, transverse aortic constriction or sham surgery was performed in 7-week-old intact and ovariectomized (OVX) rats. Three days before creating the constrictio...

Introduction. Hypertension with left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular-related morbidity. Diet plays an essential role in the prevention and treatment of chronic cardiovascular disease. The aim our study was to analyze influence 10-week diets consisting different high fats carbohydrates on myocardium spontaneously hypertensive rats (SHR). Materi...

Cardiac hypertrophy is a critical component of phenotype in the failing heart. Recently, increasing evidence has demonstrated that oxidative stress plays an important role in the pathogenesis of myocardial hypertrophy. In the present study, we generated a mouse model of transverse aortic constriction (TAC) to investigate whether hydrogen sulfide (H2S) has protective effects against cardiac hype...

QiShen YiQi Pills(®) (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases. However, the potential of QSYQ to inhibit cardiac fibrosis in left ventricle hypertrophy is not explored to date. We investigated the effects of post-treatment with QSYQ on rat myocardial fibrosis in left ventricle hypertrophy induced by pressure over-load through ascending aortic stenosis....

BACKGROUND Type 2 diabetes and the metabolic syndrome are associated with impaired diastolic function and increased heart failure risk. Animal models and autopsy studies of diabetic patients implicate myocardial fibrosis, cardiomyocyte hypertrophy, altered myocardial microvascular structure and advanced glycation end-products (AGEs) in the pathogenesis of diabetic cardiomyopathy. We investigate...

A woman with advanced coronary artery disease underwent heart transplantation. The donor heart had left ventricular hypertrophy. The electrocardiographic and echocardiographic evidence, of left ventricular hypertrophy regressed during follow up; estimated left ventricular mass decreased from 393 g to 171 g. The adaptation of myocardial mass and performance after transplantation is not fully und...

E lectrocardiography and echocardiography are widely used in hypertensive patients with the aim of identifying left-ventricular hypertrophy and its serial changes, because such changes have important prognostic implications. Detection of left-ventricular hypertrophy is, however, only one of the many applications of these diagnostic techniques. In this issue of the Journal, Cicala et al address ...

has led to an appreciation of the clinical importance of achieving regression of cardiac hypertrophy, as well as control of blood pressure, in patients receiving antihypertensive therapy. The superiority of converting enzymeinhibitors compared to other antihypertensive agents in effecting regression of cardiac hypertrophy could be attributable to their characteristic profile of actions. By inhi...