Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...

To test the hypothesis that contrast-enhanced magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) can dilferentiate reversible from irreversible myocardial injury, these modalities were used to study ischemia and reperfusion in a rat model. The presence of ischemia and reperfusion were confirmed with radiolabeled microspheres (n=6). Groups of animals were subjected to eit...

Myocardial protection from ischemic and reperfusion injury is an important task of modern experimental clinical medicine. This type damage a key link in the pathogenesis coronary heart disease and, above all, acute myocardial infarction – socio-economically significant that one main causes disability mortality adult population Republic Belarus. The aim study was to elucidate cardioprotective ef...

Aim: Acute myocardial infarction is a major cause of morbidity and mortality worldwide. Although thrombolytic therapy primary percutaneous coronary intervention are the therapeutic approaches to reduce ischemic injury limit infarct size by providing reperfusion, process can itself induce cardiomyocyte death known as reperfusion injury. In addition effects on immunsuppression for organ transplan...

While coronary thrombolytic therapy in clinical practice is well established for acute myocardial infarction, the injury associated with reperfusion ("reperfusion injury") is still under intense investigation regarding its nature and the strategy for its prevention. Reperfusion injury has been defined as cell injury caused by reperfusion itself, in contradistinction to cell injury caused by the...

BACKGROUND Polymorphonuclear leukocytes (PMNs) have been shown to mediate coronary vascular and myocardial tissue injury after coronary artery ischemia and reperfusion. Previous studies using specific monoclonal antibodies directed against P-selectin and L-selectin have demonstrated the involvement of the selectin family of glycoproteins in the early phase of PMN-induced myocardial ischemia-rep...

myocardial ischemia (mi) resulting in infarction is an important cause of mortality and morbidity worldwide. acute ischaemia rapidly impairs myocardial contractile function. myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. hibernation is now thought to be the consequence o...

Recent experimental evidence suggests that reactive nitrogen oxide species can contribute significantly to postischemic myocardial injury. The aim of the present study was to evaluate the role of two reactive nitrogen oxide species, nitroxyl (NO(-)) and nitric oxide (NO(.)), in myocardial ischemia and reperfusion injury. Rabbits were subjected to 45 min of regional myocardial ischemia followed ...

BACKGROUND Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is expressed in the heart and regulates genes involved in myocardial fatty acid oxidation (FAO). The role of PPAR-alpha in acute ischemia/reperfusion myocardial injury remains unclear. METHODS AND RESULTS The coronary arteries of male mice were ligated for 30 minutes. After reperfusion for 24 hours, ischemic and infarct ...

Sustained urban carbon monoxide (CO) exposure exacerbates heart vulnerability to ischemia-reperfusion via deleterious effects on the antioxidant status and Ca(2+) homeostasis of cardiomyocytes. The aim of this work was to evaluate whether moderate exercise training prevents these effects. Wistar rats were randomly assigned to a control group and to CO groups, living during 4 wk in simulated urb...