---・-A micronucleus test using BDFi male mice was conducted in order to evaluate the in vive mutagenicity of mofezolac (N-22). N-22 was orally administered at doses of 75, 150, 300 arid 600 mglkg, with a sampling time of 24 hr. The frequency of polychromatic erythrocytes with micronuclei was O,07-O,08% in the groups treated with N-22 and did not differ markedly from that of the vehicle control ...

We have previously determined the dietary a-linolenic requirement for membrane synthesis in the developing animal. This study measures the dietary re quirement for maintaining normal membrane compo sition in adult rats, as determined by 22:6(n-3) (docosahexaenoic acid) concentration. Sixty-day-old rats, previously fed a diet containing both linoleic and a-lino lenic acid, were divided into nine...