purpose : to evaluate the effects of memantine on improving visual function in patients with acute nonarteritic anterior ischemic optic neuropathy (naion) methods : this was a prospective, double masked, randomized, clinical trial. the study involved 47 subjects with unilateral naion of less than 8 weeks duration. eligible patients were randomly allocated to take either memantine tablets (5 mg ...

In this review, we comprehensively describe ophthalmic diseases with mitochondrial DNA mutation such as Leber's hereditary optic neuropathy (LHON), progressive external ophthalmoplegia (PEO) and Kearns-Sayre Syndrome (KSS). Ocular involvement is a prominent clinical feature of various mitochondrial diseases as well. The known mitochondrial disorders such as Mitochondrial encephalomyopathy, lact...

PURPOSE Nonarteritic anterior ischemic optic neuropathy (NAION) results in optic nerve damage with retinal ganglion cell (RGC) loss. An NAION model, rodent anterior ischemic optic neuropathy (rAION), was used to determine AION-associated mechanisms of RGC death and associated regional retinal changes. METHODS rAION was induced in male Wistar rats, and the retinas analyzed at various times aft...

In several diseases, fractal analysis has been proven useful to give contribution in diagnosis and prognosis of the patient and to improve treatments. In the present work we have evaluated the mass dimension of the vascular pattern of optic nerve head in non-glaucomatous optic neuropathic patients and healthy controls. Static fluorescein angiogram was performed and the images of the early venou...

With the pathophysiology not clearly understood and fewer than 130 cases having been reported in the literature, diabetic papillopathy presents a special challenge to the ophthalmologist. We report a case of a young patient with more than 12 years of type 1 diabetes mellitus (T1DM) on insulin with poor compliance to treatment who presented with sudden bilateral loss of vision. Ocular examinatio...

Introduction: Ophthalmology practice including neuro-ophthalmology (NO) adopted the American Academy of recommendation to provide only urgent or emergent care during COVID-19 pandemic. Objective: This report aimed present demographical and patient visit data regarding characteristic outpatient in clinic evaluate patients regulation priority mitigation according IOA guideline Methods: Retrospect...

Visual acuity and quantitative perimetry (Octopus Program 32) testing was performed in the acute (< 30 days after onset) and convalescent (> 3 months after onset) phases of disease in 27 patients with untreated NAION. Initial group mean acuity and sensitivity loss were compared to final values using the t test. Proportions of patients demonstrating a change of > 2 lines acuity or > 2 dB mean se...

The development of optical coherence tomography (OCT) has changed the clinical management of ophthalmic diseases by furthering the understanding of pathogenesis, as well as improving the monitoring of their progression and assisting in quantifying the response to treatment modalities in ophthalmic diseases. Initially, the two-dimensional configuration of the optic nerve head (ONH) and the thick...