NEW TOOLS FOR MEDICAL DIAGNOSTICS Frank F. Bier Benefits of nanotechnology for diagnostics and cell handling Pag. 1 Gianfranco Gilardi Construction of a liver-chip for drug metabolism: amperometric sensing with human cytochrome p450s Pag. 3 J Malcolm Wilkinson Micro and Nanotechnology for Drug Discovery, Drug Delivery and Diagnosis Pag. 5 Andrew Campitelli Polymer based MNT Solutions for Future...

In this study, we applied an electrospinning (ES) method, which is mainly employed in the textile industry, to the field of pharmaceuticals. We developed and modified an ES instrument and then utilized it to produce methacrylic acid copolymer S (MAC) nano-fibers to prepare tablets. By attaching a conductor rod made from stainless steel to the central part of the nano-fiber-collection plate of t...

Pluronics with different structural compositions and properties are used for several applications, including drug delivery systems. We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high ...

The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibi...

Nanoparticulate drug delivery systems (NDDSs) offer a revolutionary strategy to fighting ailments. The NDDSs are uniquely and deliberately constructed as vessels for the transport of active pharmaceutical components (APIs), which leverages their distinct physicochemical traits, such lengthened circulation period, enhanced targeting capability evasion resistance. Although last three decades have...

Nanomaterials are known as chemically or biologically engineered materials having nanodimension of 1-100nm. These have been shown to exhibit various novel properties e.g. enhanced reactivity, greater sensing capability and improved mechanical strength. Various improved procedures are still under innovative considerations to enhance the potency, safety, and efficiency of chosen plasmid DNA vecto...